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Listar por autor "Peña Mendizabal, Edurne"

Mostrando ítems 1-5 de 5

Boosting the sensitivity of in vitro b-lactam allergy diagnostic tests

Peña-Mendizábal, Edurne; Morais, Sergi; Maquieira Catala, Ángel (The Royal Society of Chemistry, 2020-10-14)

[EN] The synthesis of structurally new haptens and the development of suitable antigens are essential for boosting the sensitivity of drug allergy diagnostic testing. Unprecedented structural antigens for benzylpenicillin ...
Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

Peña-Mendizábal, Edurne; Morais, Sergi; Maquieira Catala, Ángel (Nature Publishing Group, 2020-09-29)

[EN] New antigens deriving from -lloyl and -llanyl, major and minor determinants, respectively, were produced for beta-lactam antibiotics cefuroxime, cefotaxime, ceftriaxone, meropenem and aztreonam. Twenty beta-lactam ...
Síntesis, purificación y caracterización de haptenos de amoxicilina. Aplicación al diagnóstico de alergias a antibióticos β-lactámicos

Colomer Castell, Sergi (Universitat Politècnica de València, 2019-10-02)

[ES] Los ß-lactámicos son la familia de antibióticos más consumida a día de hoy, generando la mayoría de alergias a medicamentos con una prevalencia de entre el 5 y el 10%, siendo la amoxicilina el principal inductor. ...
Synthesis and Evaluation of Antigenic Determinants for ß-lactam Allergy Diagnosis

Peña Mendizabal, Edurne (Universitat Politècnica de València, 2022-05-09)

[EN] About 10 % of all adverse drug reactions are due to allergies, with ß-lactam antibiotics causing the majority of the episodes. Although the actual incidence remains unknown, individuals suspected of being allergic to ...
Synthesis of skeletally diverse ß-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy

Peña-Mendizábal, Edurne; Hua, Bruce K.; Ibáñez-Echevarría, Ethel; Hernández-Fernández de Rojas, Dolores; Maquieira Catala, Angel; Schreiber, Stuart L.; Morais, Sergi (The Royal Society of Chemistry, 2022-05-17)

[EN] We present the first synthesis of beta-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed ...