Buscar en RiuNet

Listar

Todo RiuNet

Mi cuenta

Acceder

Ayuda RiuNet

Admin. UPV

Listar por autor "González Cardenete, Miguel Ángel"

Mostrando ítems 1-13 de 13

A Short and Improved Synthesis of the Antiprotozoal Abietane Diterpenoid (-)-Sugikurojin A

González-Cardenete, Miguel A; Zaragoza, Ramon J. (Georg Thieme Verlag KG, 2017-03)
Anti-Zika virus activity of several abietane-type ferruginol analogues

Sousa, Francielle T. G.; Nunes, Cristina; Malta Romano, Camila; Cerdeira Sabino, Ester; González-Cardenete, Miguel A (Universidade de São Paulo (USP), 2020)

[EN] Abietane diterpenoids are naturally occurring plant metabolites with a broad spectrum of biological effects including antibacterial. antileishmanial, antitumor, antioxidant, as well as antiinfiammatory activities. ...
Anticoronavirus Evaluation of Antimicrobial Diterpenoids: Application of New Ferruginol Analogues

Varbanov, Mihayl; Philippot, Stephanie; González-Cardenete, Miguel A. (MDPI AG, 2023-06)

[EN] The abietane diterpene (+)-ferruginol (1), like other natural and semisynthetic abietanes, is distinguished for its interesting pharmacological properties such as antimicrobial activity, including antiviral. In this ...
Antifungal Activity of Amphiphilic Perylene Bisimides

Roa-Linares, Vicky C.; Mesa-Arango, Ana C.; Zaragoza, Ramon J.; González-Cardenete, Miguel A (MDPI AG, 2022-10)

[EN] Perylene-based compounds, either naturally occurring or synthetic, have shown interesting biological activities. In this study, we report on the broad-spectrum antifungal properties of two lead amphiphilic perylene ...
Antiviral Profiling of C-18-or C-19-Functionalized Semisynthetic Abietane Diterpenoids

González-Cardenete, Miguel A; Hamulic, Damir; Miquel-Leal, Francisco J.; González-Zapata, Natalia; Jimenez-Jarava, Orlando J.; Brand, Yaneth M.; Restrepo-Mendez, Laura C.; Martinez-Gutierrez, Marlen; Betancur-Galvis, Liliana A.; Marín García, Mª Luisa (American Chemical Society, 2022-08-26)

[EN] Viral infections affect several million patients annually. Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy ...
Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues

González-Cardenete, Miguel A; Rivas, Fatima; Basset, Rachel; Stadler, Marco; Hering, Steffen; Padrón, José M.; Zaragozá, Ramón J.; Dea-Ayuela, Maria Auxiliadora (MDPI AG, 2021-02)

[EN] The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid ...
Desarrollo y síntesis sostenible de nuevas moléculas antitumorales utilizando biomasa como fuente renovable

Mendoza Hernández, William Ernesto (Universitat Politècnica de València, 2024-09-05)

[ES] La familia de ácidos resínicos diterpénicos presenta diversas aplicaciones farmacológicas, habiendo demostrado actividad antiviral, antitumoral y antibacteriana. Sin embargo, a pesar de estas propiedades biológicas ...
Desarrollo, escalado y validación de la síntesis del antiviral 18-(phthalimid-2-yl) ferruginol contra enfermedades tropicales causadas por los virus Dengue-2 (DENV-2) y Zika (ZIKV) de prevalencia en América Latina

González Zapata, Natalia (Universitat Politècnica de València, 2022-07-26)

[ES] En el marco de una pandemia mundial producida por el SARS-CoV-2 se reafirma la necesidad imperiosa de continuar las líneas de investigación relacionadas con infecciones producidas por virus. En zonas de América Latina ...
Discovery of Novel Bioactive Tanshinones and Carnosol Analogues against Breast Cancer

González-Cardenete, Miguel A; González-Zapata, Natalia; Boyd, Lucinda; Rivas, Fatima (MDPI AG, 2023-02)

[EN] The abietane diterpenoids ferruginol (1), tanshinone IIA (3), and carnosol (4) are well-known for their interesting pharmacological properties, including antitumor, similar to other natural and semisynthetic abietanes. ...
First diastereoselective synthesis of (-)-methyl thyrsiflorin A, (-)- methyl thyrsiflorin B acetate, and (-)-thyrsiflorin C

Arnó, Manuel; González-Cardenete, Miguel A; Marín, M. Luisa; Zaragoza, Ramón J. (American Chemical Society, 2000-02-11)

An efficient procedure for the synthesis of scopadulan diterpenes, using (+)-podocarp-8(14)-en-13- one 13 as starting material, is reported. This procedure has been used for the diastereoselective synthesis of (-)-methyl ...
Semisynthetic Abietic and Dehydroabietic Acid Derivatives and Triptoquinone Epimers Interfere with LPS-Triggered Activation of Dendritic Cells

Sierra, Jelver A.; Gilchrist, Katherine; Tabares-Guevara, Jorge H.; Betancur-Galvis, Liliana; Ramírez-Pineda, José R.; González-Cardenete, Miguel A (MDPI AG, 2022-10)

[EN] Abietic acid (AA), dehydroabietic acid (DHA) and triptoquinones (TQs) are bioactive abietane-type diterpenoids, which are present in many edible vegetables and medicinal herbs with health-promoting properties. Evidence ...
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

Hamulic, Damir; Stadler, Marco; Hering, Steffen; Padron, Jose M.; Bassett, Rachel; Rivas, Fatima; Loza-Mejia, Marco; Dea-Ayuela, M. Auxiliadora; González-Cardenete, Miguel A (American Chemical Society, 2019-04)

[EN] The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily ...
Synthesis of bodinieric acids A and B, both C-18 and C-19-functionalized abietane diterpenoids: DFT study of the key aldol reaction

Zaragoza, Ramon J.; González-Cardenete, Miguel A (The Royal Society of Chemistry, 2020-04-15)

[EN] The first synthesis of C-18- and C-19-bifunctionalized abietane diterpenoids, bodinieric (or callicapoic) acids, via an aldol reaction has been developed. This key aldol reaction was very sensitive to steric hindrance. ...