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Listar por autor "Alfonso Navarro, María"

Mostrando ítems 1-13 de 13

A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

Hernández-Montoto, Andy; Gorbe, Mónica; Llopis-Lorente, Antoni; Terrés-Haro, José Manuel; Montes-Robles, Roberto; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Orzaez, Mar; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (The Royal Society of Chemistry, 2019-08-07)

[EN] Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power ...
A sensitive nanosensor for the in situ detection of the cannibal drug

Garrido-García, Eva María; Alfonso-Navarro, María; Díaz de Greñu-Puertas, Borja; Marcos Martínez, María Dolores; Costero, Ana M.; Gil Grau, Salvador; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (American Chemical Society, 2020-09-25)

[EN] A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4- methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous ...
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration

Yu, Qinghao; Walters, Hannah E.; Pasquini, Giovanni; Singh, Sumeet Pal; Lachnit, Martina; Oliveira, Catarina R.; León-Periñán, Daniel; Petzold, Andreas; Kesavan, Preethi; Adrados, Cristina Subiran; Garteizgogeascoa, Ines; Knapp, Dunja; Wagner, Anne; Bernardos Bau, Andrea; Alfonso, María; Martínez-Máñez, Ramón (Elsevier, 2023-11-20)

[EN] Axolotl limb regeneration is accompanied by the transient induction of cellular senescence within the blastema, the structure that nucleates regeneration. The precise role of this blastemal senescent cell (bSC) ...
Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Candela-Noguera, Vicente; Vivo-Llorca, Gema; Díaz de Greñu, Borja; Alfonso, María; Aznar, Elena; Orzáez, Mar; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (MDPI AG, 2021-05)

[EN] We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved ...
In-depth study of factors affecting the formation of MCM-41-type mesoporous silica nanoparticles

Candela-Noguera, Vicente; Alfonso, María; Amorós, Pedro; Aznar, Elena; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón (Elsevier, 2024-01-01)

[EN] Mesoporous silica nanoparticles (MSN), especially MCM-41 type, have been broadly studied and used in different applications such as catalysis, nanomedicine and environmental science. One of the most advantageous ...
Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain

Sánchez-Dengra, Barbara; Alfonso, María; Gonzalez-Alvarez, Isabel; Bermejo, Marival; Gonzalez -Alvarez, Marta; Martínez-Máñez, Ramón (Future Medicine, 2023-10)

[EN] Background: Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood-brain barrier is limiting the development of new treatments directed toward the brain, ...
Janus Gold Nanostars-Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery

Hernández-Montoto, Andy; Llopis-Lorente, Antoni; Gorbe, Mónica; Terrés-Haro, José Manuel; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Ibáñez Civera, Francisco Javier; Marcos Martínez, María Dolores; Orzaez, Mar; Villalonga, R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (John Wiley & Sons, 2019-05-27)

[EN] Janus gold nanostar-mesoporous silica nanoparticle (AuNSt-MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was ...
MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Vivo-Llorca, Gema; Candela-Noguera, Vicente; Alfonso-Navarro, María; García-Fernández, Alba; Orzáez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (John Wiley & Sons, 2020-10-09)

[EN] Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been ...
Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe

Garrido-García, Eva María; Alfonso-Navarro, María; Díaz de Greñu-Puertas, Borja; Lozano-Torres, Beatriz; Parra Álvarez, Margarita; Gaviña, Pablo; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (John Wiley & Sons, 2020-03-02)

[EN] This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded ...
Peptide-Capped Mesoporous Nanoparticles: Toward a more Efficient Internalization of Alendronate

Añón, Elena; Costero, Ana M.; Amorós del Toro, Pedro; El Haskouri, Jamal; Martínez-Máñez, Ramón; Parra Álvarez, Margarita; Gil Grau, Salvador; Gaviña, Pablo; Terencio Silvestre, María Carmen; Alfonso-Navarro, María (John Wiley & Sons, 2020-03-31)

[EN] Osteoporosis is an illness which appears when the osteoblast/osteoclast activities are unbalanced taking place bone resorption (caused by osteoclasts) in higher extension than bone formation (induced by osteoblasts). ...
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Lerida-Viso, Araceli; Estepa-Fernández, Alejandra; Morella-Aucejo, Ángela; Lozano-Torres, Beatriz; Alfonso, María; Blandez, Juan F.; Bisbal, Viviana; Sepúlveda, Pilar; García-Fernández, Alba; Orzáez, Mar; Martínez-Máñez, Ramón (Elsevier, 2022-09)

[EN] Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of ...
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic

Galiana, Irene; Lozano-Torres, Beatriz; Sancho, Mónica; Alfonso-Navarro, María; Bernardos Bau, Andrea; Bisbal, Viviana; Serrano, Manuel; Martínez-Máñez, Ramón; Orzaez, Mar (Elsevier, 2020-07)

[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, ...
Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue

Lozano-Torres, Beatriz; Blandez, Juan F.; Galiana, Irene; García-Fernández, Alba; Alfonso-Navarro, María; Marcos Martínez, María Dolores; Orzáez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (John Wiley & Sons, 2020-08-24)

[EN] In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 ...