Hernández-Montoto, Andy; Gorbe, Mónica; Llopis-Lorente, Antoni; Terrés-Haro, José Manuel; Montes-Robles, Roberto; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Orzaez, Mar; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(The Royal Society of Chemistry, 2019-08-07)
[EN] Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power ...
Bernardos Bau, Andrea; Mondragón Martínez, Laura; Javakhishvili, Irakli; Mas Font, Nuria; De la Torre Paredes, Cristina; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Barat Baviera, José Manuel; Hvilsted, Soren; Orzaez, Mar; Pérez Payá, Enrique; Amorós, Pedro(Wiley-VCH Verlag, 2012-10-08)
The synthesis and characterisation of new capped silica mesoporous nanoparticles for on-command delivery applications is reported. Functional capped hybrid systems consist of MCM-41 nanoparticles functionalised on the ...
[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been ...
[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous ...
Hernández-Montoto, Andy; Llopis-Lorente, Antoni; Gorbe, Mónica; Terrés-Haro, José Manuel; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Ibáñez Civera, Francisco Javier; Marcos Martínez, María Dolores; Orzaez, Mar; Villalonga, R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(John Wiley & Sons, 2019-05-27)
[EN] Janus gold nanostar-mesoporous silica nanoparticle (AuNSt-MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was ...
[EN] Mucin 1 (MUC1) is a cell surface protein overexpressed in breast cancer. Mesoporous silica nanoparticles (MSNs) loaded with safranin O, functionalized with aminopropyl groups and gated with the negatively charged MUC1 ...
García-Fernández, Alba; Vivo-Llorca, Gema; Sancho, Mónica; García-Jareño, Alicia Belén; Ramírez-Jiménez, Laura; Barber-Cano, Eloísa; Murguía, Jose R.; Orzaez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2022-07)
[EN] In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of ...
[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, ...
García-Fernández, Alba; García-Laínez, G.; Ferrandiz Manglano, Mª Luisa; Aznar, Elena; Sancenón Galarza, Félix; Alcaraz, Mª Jose; Murguía, Jose R.; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Costero, Ana M.; Orzaez, Mar(Elsevier, 2017)
[EN] Acute inflammation is a protective response of the body to harmful stimuli, such as pathogens or damaged cells. However, dysregulated inflammation can cause secondary damage and could thus contribute to the pathophysiology ...
de la Torre, Cristina; Agostini, Alessandro; Mondragón Martínez, Laura; Orzaez, Mar; Sancenón Galarza, Félix; Martínez Mañez, Ramón; Marcos Martínez, María Dolores; Amoros, Pedro; Pérez Payá, Enrique(Royal Society of Chemistry, 2014)
Changes in the conformation of a peptide anchored onto the external surface of mesoporous silica nanoparticles have been used to design novel temperature-controlled delivery systems.