De la Iglesia Jordán, Francisca; Martinez Garcia, Fernando; Hillung, Julia; Cuevas Torrijos, Jose Manuel; Gerrish, Philip J.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(American Society for Microbiology, 2012)
[EN] A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbruck ...
Martinez Garcia, Fernando; Lafforgue, Guillaume; Morelli, M.; González-Candelas, F.; CHUA, N.H.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2012-11)
[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...