Llaneras Estrada, Francisco; Sala, Antonio; Picó Marco, Jesús Andrés(Elsevier, 2012-12)
Living cells can be modelled by successively imposing known constraints that limit their behaviour, such as mass balances, thermodynamic laws or enzyme capacities. The resulting constraint-based models enclose all the ...
[EN] A previously validated constraint based model and possibilistic MFA have been used to design a simple estimator of protein production rate in Pichia pastoris cultures. A structured model of the yeast P. pastoris ...
Llaneras Estrada, Francisco(Universitat Politècnica de València, 2011-03-23)
This thesis is devoted to the study and application of constraint-based metabolic models. The objective was to find simple ways to handle the difficulties that arise in practice due to uncertainty (knowledge is incomplete, ...
Folch-Fortuny, Abel; Tortajada Serra, Marta; Prats-Montalbán, José Manuel; Llaneras Estrada, Francisco; Picó Marco, Jesús Andrés; Ferrer Riquelme, Alberto José(Elsevier, 2015-03-15)
[EN] With the aim of understanding the flux distributions across a metabolic network, i.e. within living cells, Principal Component Analysis (PCA) has been proposed to obtain a set of orthogonal components (pathways) ...
[EN] Within the emergent field of Systems Biology, mathematical models obtained from physical chemical laws (the so-called first principles-based models) of microbial systems are employed to discern the principles that ...