Oral administration of camptothecin (Cm) derivatives and other antitumoral agents is being actively developed in order to improve the quality of life of patients with cancer. Though several lipophilic derivatives of CPT ...
[EN] Demonstration of similar microstructure is essential for demonstrating the equivalence of generic topical products since the microstructure of semisolids may affect the drug release. The objective of this study was ...
[EN] Inter- and intra-batch variability of the quality attributes contribute to the uncertainty for demonstrating equivalent microstructure of post-approval changes and generic/hybrids of semisolid topical products. Selecting ...
Rodríguez-Fernández, Karine; Reynaldo-Fernández, G.; Reyes-González, Stephanie; de las Barreras, Camila; Rodríguez-Vera, Leyanis; Vlaar, Cornelis; Monbaliu, Jean-Christophe M.; Stelzer, Torsten; Duconge, Jorge; Mangas-Sanjuan, Victor(Elsevier, 2024-01)
[EN] Warfarin, an oral anticoagulant, has been used for decades to prevent thromboembolic events. The complex interplay between CYP2C9 and VKORC1 genotypes on warfarin PK and PD properties is not fully understood in special ...