[EN] Penicillin is one of the most widely used antibiotics to treat bacterial infections in clinical practice. The antibiotic
undergoes degradation under physiological conditions to produce reactive compounds that in vivo ...
Doña, Inmaculada; Pérez-Sánchez, Natalia; Salas, María; Barrionuevo, Esther; Ruiz-San Francisco, Arturo; Hernández Fernández de Rojas, Dolores; Martí-Garrido, Jaume; Andreu Ros, María Inmaculada; López-Salgueiro, Ramón; Moreno, Esther; Torres, María José(Elsevier, 2020-09)
[EN] BACKGROUND: Quinolones are the second most frequent cause of hypersensitivity reactions (HSRs) to antibiotics. A marked increase in the number of patients with HSRs to quinolones has been detected.
OBJECTIVE: To ...
Parra Hernández, Ana(Universitat Politècnica de València, 2020-10-02)
[ES] La alergia es una de las enfermedades inmunológicas con más repercusión a nivel mundial. Desde el punto de vista clínico, la alergia se define como una respuesta exacerbada del propio sistema inmunitario contra ciertas ...
Juárez-Rodríguez, María José; Ibáñez-Echevarría, Ethel; Hernández-Fernández de Rojas, Dolores; Maquieira, Angel; Morais, Sergi(Elsevier, 2021-08-15)
[EN] The suspicion of beta-lactam allergy directly contributes to the prescription of antibiotics that diverge from the guidelines, increasing antimicrobial resistance, one of the biggest threats to global health. In vitro ...
Peña-Mendizábal, Edurne; Hua, Bruce K.; Ibáñez-Echevarría, Ethel; Hernández-Fernández de Rojas, Dolores; Maquieira Catala, Angel; Schreiber, Stuart L.; Morais, Sergi(The Royal Society of Chemistry, 2022-05-17)
[EN] We present the first synthesis of beta-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed ...