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Squaramide-Tethered Sulfonamides and Coumarins: Synthesis, Inhibition of Tumor-Associated CAs IX and XII and Docking Simulations

Arrighi, Giulia; Puerta, Adrián; Petrini, Andrea; Hicke-García, Francisco Javier; Nocentini, Alessio; Fernandes, Miguel X.; Padrón, José M.; Supuran, Claudiu T.; Fernández-Bolaños, José G.; López, Óscar (MDPI AG, 2022-07)

[EN] (1) Background: carbonic anhydrases (CAs) are attractive targets for the development of new anticancer therapies; in particular, CAs IX and XII isoforms are overexpressed in numerous tumors. (2) Methods: following the ...
Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents

Hicke-García, Francisco Javier; Puerta, Adrián; Dinic, Jelena; Pesic, Milica; Padrón, José M.; López, Óscar; Fernández-Bolaños, José G. (Elsevier, 2022-01-15)

[EN] The necessity for developing novel cytostatic agents with improved activities and reduced side-effects to tackle cancer prompted us to investigate mitochondria-targeted compounds, an approach that is gaining attention ...

Mostrando ítems 1-2 de 2