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Listar por autor "Ouardi el Hamidy, Meryem el"

Mostrando ítems 1-6 de 6

Cellular photo(geno)toxicity of gefitinib after biotransformation

El Ouardi, Meryem; Tamarit-Mayo, Lorena; Vayá Pérez, Ignacio; Miranda, Miguel A.; Andreu, Inmaculada (Frontiers Media SA, 2023-06-07)

[EN] Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads ...
In Vitro Photobehavior of Tyrosine Kinase Inhibitors in Solution and within Skin Cells

Ouardi el Hamidy, Meryem el (Universitat Politècnica de València, 2024-07-11)

[ES] En las últimas décadas, la aprobación de los inhibidores de la tirosina quinasa (del inglés TKI) como una nueva clase de terapia dirigida ha mejorado la calidad de vida y las tasas de supervivencia de los pacientes ...
Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Vayá Pérez, Ignacio (Frontiers Media SA, 2024-05-16)

[EN] The photobiological damage that certain drugs or their metabolites can photosensitize in proteins is generally associated with the nature of the excited species that are generated upon interaction with UVA light. In ...
Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to the cell

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Andreu Ros, María Inmaculada; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2021-09-28)

[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on ...
Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir

García-Laínez, Guillermo; El Ouardi, Meryem; Moreno, Alejandro; Lence, Emilio; González-Bello, Concepción; Miranda, Miguel Á.; Andreu, Inmaculada (Elsevier, 2023-01)

[EN] Hepatitis C, a liver inflammation caused by the hepatitis C virus (HCV), is treated with antiviral drugs. In this context, simeprevir (SIM) is an NS3/4A protease inhibitor used in HCV genotypes 1 and 4. It is orally ...
Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2022-08-24)

[EN] Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase ...