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Listar por autor "Ouardi el Hamidy, Meryem el"

Mostrando ítems 1-5 de 5

Cellular photo(geno)toxicity of gefitinib after biotransformation

El Ouardi, Meryem; Tamarit-Mayo, Lorena; Vayá Pérez, Ignacio; Miranda, Miguel A.; Andreu, Inmaculada (Frontiers Media SA, 2023-06-07)

[EN] Gefitinib (GFT) is a selective epidermal growth factor receptor (EGFR) inhibitor clinically used for the treatment of patients with non-small cell lung cancer. Bioactivation by mainly Phase I hepatic metabolism leads ...
In Vitro Photobehavior of Tyrosine Kinase Inhibitors in Solution and within Skin Cells

Ouardi el Hamidy, Meryem el (Universitat Politècnica de València, 2024-07-11)

[ES] En las últimas décadas, la aprobación de los inhibidores de la tirosina quinasa (del inglés TKI) como una nueva clase de terapia dirigida ha mejorado la calidad de vida y las tasas de supervivencia de los pacientes ...
Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to the cell

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Andreu Ros, María Inmaculada; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2021-09-28)

[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on ...
Singlet oxygen and radical-mediated mechanisms in the oxidative cellular damage photosensitized by the protease inhibitor simeprevir

García-Laínez, Guillermo; El Ouardi, Meryem; Moreno, Alejandro; Lence, Emilio; González-Bello, Concepción; Miranda, Miguel Á.; Andreu, Inmaculada (Elsevier, 2023-01)

[EN] Hepatitis C, a liver inflammation caused by the hepatitis C virus (HCV), is treated with antiviral drugs. In this context, simeprevir (SIM) is an NS3/4A protease inhibitor used in HCV genotypes 1 and 4. It is orally ...
Switching from ultrafast electron transfer to proton transfer in excited drug-protein complexes upon biotransformation

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2022-08-24)

[EN] Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase ...