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Listar por autor "García-Laínez, G."

Mostrando ítems 1-2 de 2

In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor

García-Laínez, G.; Vayá Pérez, Ignacio; Marín, Mª Pilar; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Springer-Verlag, 2021-01)

[EN] The epidermal growth factor receptors EGFR and HER2 are the main targets for tyrosine kinase inhibitors (TKIs). The quinazoline derivative lapatinib (LAP) is used since 2007 as dual TKI in the treatment of metastatic ...
Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (American Chemical Society, 2018-03)

[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...

Mostrando ítems 1-2 de 2