[EN] Over millions of years, eukaryotes evolved from unicellular to multicellular organisms with increasingly complex genomes and sophisticated gene expression networks. Consequently, chromatin regulators evolved to support ...
Wongpalee, Somsakul Pop; Liu, Shiheng; Gallego Bartolomé, Javier; Leitner, Alexander; Aebersold, Ruedi; Liu, Wanlu; Yen, Linda; Nohales, Maria A.; Kuo, Peggy Hsuanyu; Vashisht, Ajay A.; Wohlschlegel, James A.; Feng, Suhua; Kay, Steve A.; Zhou, Z. Hong; Jacobsen, Steven E.(Nature Publishing Group, 2019-09-02)
[EN]
Transcription by RNA polymerase V (Pol V) in plants is required for RNA-directed DNA methylation, leading to transcriptional gene silencing. Global chromatin association of Pol V requires components of the DDR complex ...
Zhong, Xuehua; Du, Jiamu; Hale, Christopher J; Gallego Bartolomé, Javier; Feng, Suhua; Vashisht, Ajay A.; Chory, Joanne; Wohlschlegel, James A.; Patel, Dinshaw J.; Jacobsen, Steven E.(Elsevier, 2014-05-26)
[EN]
DNA methylation is a conserved epigenetic generegulation mechanism. DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood. ...