Buscar en RiuNet

Listar

Todo RiuNet

Mi cuenta

Acceder

Ayuda RiuNet

Admin. UPV

Listar por autor "Rajamani, Sridharan"

Mostrando ítems 1-5 de 5

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

Yang, Pei-Chi; El-Bizri, Nesrine; Romero Pérez, Lucia; Giles, Wayne; Rajamani, Sridharan; Belardinelli, Luiz; Clancy, Colleen E (Elsevier, 2016)

[EN] Background: The QT interval is a phase of the cardiac cycle that corresponds to action potential duration (APD) including cellular repolarization (T-wave). In both clinical and experimental settings, prolongation of ...
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R. (Frontiers Media, 2013-10)

Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and ...
In silico assessment of drug safety in human heart applied to late sodium current blockers

Trénor Gomis, Beatriz Ana; Gomis-Tena Dolz, Julio; Cardona Urrego, Karen Eliana; Romero Pérez, Lucia; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R.; Saiz Rodríguez, Francisco Javier (Landes Bioscience, 2013-07-01)

Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...
Pro-arrhythmic Effects of Low Plasma [K+] in Human Ventricle: An Illustrated Review

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Romero Pérez, Lucia; Gómez García, Juan Francisco; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne (Elsevier, 2018)

[EN] Potassium levels in the plasma, [Kþ]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to 8.0 mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult ...
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier (Public Library of Science, 2012)

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...