In cardiotoxicity studies it is common to pre-compute the values of different biomarkers (my equation or TX) for a range of ion channel blockades. Since every simulation requires costly computations, to complete the matrix ...
[EN] Background and Objective
In silico prediction of drug-induced ventricular arrhythmia often requires computationally intensive simulations, making its application tedious and non-interactive. This inconvenience can ...
[EN] Drug-induced proarrhythmicity is a major concern for regulators and pharmaceutical companies. For novel drug candidates, the standard assessment involves the evaluation of the potassium hERG channels block and the in ...
[EN] In silico methods can be used for an early assessment of arrhythmogenic properties of drug candidates. However, their use for decision-making is conditioned by the possibility to estimate the predictions' uncertainty. ...