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Listar por autor "Yang, Pei-Chi"

Mostrando ítems 1-3 de 3

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

Yang, Pei-Chi; El-Bizri, Nesrine; Romero Pérez, Lucia; Giles, Wayne; Rajamani, Sridharan; Belardinelli, Luiz; Clancy, Colleen E (Elsevier, 2016)

[EN] Background: The QT interval is a phase of the cardiac cycle that corresponds to action potential duration (APD) including cellular repolarization (T-wave). In both clinical and experimental settings, prolongation of ...
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Romero Pérez, Lucia; Trénor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E. (Elsevier, 2014-07)

Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to unmask some latent mutations linked ...
When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

Gomis-Tena Dolz, Julio; Brown, Brandon M.; Cano, Jordi; Trenor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E.; Romero Pérez, Lucia (American Chemical Society, 2020-03-23)

[EN] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-a-go-go-related gene (hERG) channels, which is currently quantified by the ...

Mostrando ítems 1-3 de 3

Listar por autor "Yang, Pei-Chi"

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Listar por autor "Yang, Pei-Chi"