[EN] Organisms have different circuitries that allow converting signal molecule levels to changes in gene expression. An important challenge in synthetic biology involves the de novo design of RNA modules enabling dynamic ...
Rodrigo Tarrega, Guillermo; Majer, Eszter; Prakash, Satya; Daros Arnau, Jose Antonio; Jaramillo, Alfonso; Poyatos, Juan F.(Biophysical Society, 2015-09-01)
[EN] The regulation of gene expression, triggered by conformational changes in RNA molecules, is widely observed in cellular systems. Here, we examine this mode of control by means of a model-based design and construction ...
Rodrigo Tarrega, Guillermo; Landrain, Thomas E.; Majer, Eszter; Daros Arnau, Jose Antonio; Jaramillo, Alfonso(Public Library of Science, 2013-08)
[EN] Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 59 untranslated
region of the mRNA. We have developed a physicochemical framework, relying on base pair ...
[EN] In order to explore the possibility of adding new functions to preexisting genes, we considered a framework of riboregulation. We created a new riboregulator consisting of the reverse complement of a known riboregulator. ...
Rodrigo Tarrega, Guillermo; Jaramillo, Alfonso; Blazquez Rodriguez, Miguel Angel(Elsevier, 2011)
The interplay between hormone signaling and gene regulatory networks is instrumental in promoting the development of living organisms. In particular, plants have evolved mechanisms to sense gravity and orient themselves ...
Rodrigo, Guillermo; Prakash, Satya; Shen, Shensi; Majer, Eszter; DAROS ARNAU, JOSE ANTONIO; Jaramillo, Alfonso(Oxford University Press, 2017-09-19)
[EN] Synthetic gene circuits allow the behavior of living cells to be reprogrammed, and non-coding small RNAs (sRNAs) are increasingly being used as programmable regulators of gene expression. However, sRNAs (natural or ...
Rodrigo Tarrega, Guillermo; Carrera, Javier; Jaramillo, Alfonso; Elena Fito, Santiago Fco(Royal Society, The, 2011-02-06)
[EN] The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action triggered by the intracellular ...