Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2020-12-04)
[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Fraga-Timiraos, Ana Belén; Francés-Monerris, Antonio; Rodríguez Muñiz, Gemma María; Navarrete-Miguel, Miriam; Miranda Alonso, Miguel Ángel; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria(John Wiley & Sons, 2018-10-12)
[EN] Azetidines are interesting compounds in medicine and chemistry as bioactive scaffolds and synthetic intermediates. However, photochemical processes involved in the generation and fate of azetidine-derived radical ions ...
Blasco-Brusola, Alejandro; Navarrete-Miguel, Miriam; Giussani, Angelo; Roca-Sanjuan, Daniel; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2020-09-21)
[EN] The photoinduced cycloreversion of oxetanes has been thoroughly investigated in connection with the photorepair of the well-known DNA (6-4) photoproducts. In the present work, the direct photolysis of the two regioisomers ...
Navarrete-Miguel, Miriam; Francés-Monerris, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Roca-Sanjuan, Daniel(MDPI AG, 2021-05)
[EN] Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) ...