[EN] Laminins (LMs) are important structural proteins of the extracellular matrix (ECM). The abundance of every LM isoform is tissue-dependent, suggesting that LM has tissue-specific roles. LM binds growth factors (GFs), ...
Schofield, Christina L.; Rodrigo-Navarro, Aleixandre; Dalby, Matthew J.; Van Agtmael, Tom; Salmerón Sánchez, Manuel(Wiley-VCH Verlag GmbH & Co. KGaA, 2021-05)
[EN] Central nervous system (CNS) pathologies are a prevalent problem in aging populations, creating a need to understand the underlying events in these diseases and develop efficient CNS-targeting drugs. The importance ...
[EN] Mesenchymal stem cells represent an important resource, for bone regenerative medicine and therapeutic applications. This review focuses on new advancements and biophysical tools which exploit different physical and ...
Ballester Beltrán, José; Trujillo, Sara; Alakpa, Enateri V.; Compañ Moreno, Vicente; Gavara, Rafael; Meek, Dominic; West, Christopher C.; Peault, Bruno; Dalby, Matthew J.; Salmerón Sánchez, Manuel(American Chemical Society, 2017)
[EN] Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist ...
[EN] Extracellular matrix (ECM)-derived matrices such as Matrigel are used to culture numerous cell types in vitro as they recapitulate ECM properties that support cell growth, organisation, migration and differentiation. ...
Rodrigo-Navarro, Aleixandre; Sankaran, Shrikrishnan; Dalby, Matthew J.; del Campo, Aránzazu; Salmerón Sánchez, Manuel(Nature Publishing Group, 2021-12)
[EN] Biomaterials have evolved from inert materials that lack interaction with the body to biologically active, instructive materials that host and provide signals to surrounding cells and tissues. Engineered living materials ...
[EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...
Sprott, Mark Robert; Ferrer, GG; Dalby, Matthew J.; Salmerón Sánchez, Manuel; Cantini, Marco(Wiley-VCH, 2019-02-07)
[EN] Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently ...
González García, Cristina; Moratal Pérez, David; Oreffo, Richard O.C.; Dalby, Matthew J.; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2012)
A family of polymer substrates which consists of a vinyl backbone chain with the side groups -COO(CH2)(x)H, with x = 1, 2, 4, was prepared. Substrates with similar chemical groups but decreasing stiffness, characterized ...
Luo, Jiajun; Walker, Matthew; Xiao, Yinbo; Donnelly, Hannah; Dalby, Matthew J.; Salmerón Sánchez, Manuel(Ke Ai Publishing Communications Ltd., 2022-09)
[EN] Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment ...
[EN] While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination ...