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Listar por autor "Santos-Oliveira, Ralph"

Mostrando ítems 1-5 de 5

Drug metabolism: Comparison of biodistribution profile of holmium in three different compositions in healthy Wistar rats

Cerqueira-Coutinho, Cristal; Pascual Vidal, Lluís; Pinto, Suyene Rocha; Santos-Oliveira, Ralph (Elsevier, 2016-06)

Radioisotope holmium is a candidate to be used in cancer treatment and diagnosis. There are different holmium salts and they present distinct solubility and consequently different biodistribution profiles. In this work, ...
Effect of obesity on biodistribution of nanoparticles

Felismino, Claudiana de Jesus; Helal-Neto, E.; Portilho, F.L.; Rocha Pinto, Suyene; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Ferreira, Agatha de Assis; da Silva, Simone Vargas; Barja-Fidalgo, Thereza Christina; Santos-Oliveira, Ralph (Elsevier, 2018-07-10)

[EN] Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated ...
Indirect calculation of monoclonal antibodies in nanoparticles using the radiolabeling process with technetium 99 metastable as primary factor: Alternative methodology for the entrapment efficiency

Helal-Neto, E.; Sánchez-Cabezas, Santiago; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Santos-Oliveira, Ralph (Elsevier, 2018-05-10)

[EN] The use of monoclonal antibodies (Mab) in the current medicine is increasing. Antibody-drug conjugates (ADCs) represents an increasingly and important modality for treating several types of cancer. In this area, the ...
MUC1 aptamer-capped mesoporous silica nanoparticles for controlled drug delivery and radio-imaging applications

Pascual, Lluís; Cerqueira, Cristal; García-Fernández, Alba; de Luis-Fernández, Beatriz; Soares, Emerson; Souza, Marta; Missailidis, Sotiris; Martínez-Máñez, Ramón; Santos-Oliveira, Ralph; Orzaez, Mar; Sancenón Galarza, Félix (Elsevier, 2017)

[EN] Mucin 1 (MUC1) is a cell surface protein overexpressed in breast cancer. Mesoporous silica nanoparticles (MSNs) loaded with safranin O, functionalized with aminopropyl groups and gated with the negatively charged MUC1 ...
Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals

Rezende dos Reis, Sara Rhaissa; Rocha Pinto, Suyene; Duarte de Menezes, Frederico; Martínez-Máñez, Ramón; Ricci-Junior, Eduardo; Rebelo Alencar, Luciana Magalhaes; Helal-Neto, Edward; Da Silva De Barros, Aline Oliveira; Lisboa, Patricia Cristina; Santos-Oliveira, Ralph (Springer-Verlag, 2020-01-22)

[EN] Purposes Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies ...

Mostrando ítems 1-5 de 5

Listar por autor "Santos-Oliveira, Ralph"

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Listar por autor "Santos-Oliveira, Ralph"