Radioisotope holmium is a candidate to be used in cancer treatment and diagnosis. There are different holmium salts and they present distinct solubility and consequently different biodistribution profiles. In this work, ...
Felismino, Claudiana de Jesus; Helal-Neto, E.; Portilho, F.L.; Rocha Pinto, Suyene; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Ferreira, Agatha de Assis; da Silva, Simone Vargas; Barja-Fidalgo, Thereza Christina; Santos-Oliveira, Ralph(Elsevier, 2018-07-10)
[EN] Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated ...
[EN] The use of monoclonal antibodies (Mab) in the current medicine is increasing. Antibody-drug conjugates (ADCs) represents an increasingly and important modality for treating several types of cancer. In this area, the ...
[EN] Mucin 1 (MUC1) is a cell surface protein overexpressed in breast cancer. Mesoporous silica nanoparticles (MSNs) loaded with safranin O, functionalized with aminopropyl groups and gated with the negatively charged MUC1 ...
Rezende dos Reis, Sara Rhaissa; Rocha Pinto, Suyene; Duarte de Menezes, Frederico; Martínez-Máñez, Ramón; Ricci-Junior, Eduardo; Rebelo Alencar, Luciana Magalhaes; Helal-Neto, Edward; Da Silva De Barros, Aline Oliveira; Lisboa, Patricia Cristina; Santos-Oliveira, Ralph(Springer-Verlag, 2020-01-22)
[EN] Purposes Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies ...