[EN] Background: The QT interval is a phase of the cardiac cycle that corresponds to action potential duration (APD) including cellular repolarization (T-wave). In both clinical and experimental settings, prolongation of ...
Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R.(Frontiers Media, 2013-10)
Carbon monoxide (CO) that is produced in a number of different mammalian tissues is
now known to have significant effects on the cardiovascular system. These include: (i)
vasodilation, (ii) changes in heart rate and ...
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development
of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...
[EN] Potassium levels in the plasma, [Kþ]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to
8.0 mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult ...
Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier(Public Library of Science, 2012)
Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...