Pavanello, Alice; Fabbri, Debora; Calza, Paola; Battiston, Debora; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa(Elsevier, 2022-04)
[EN] Noscapine (NSC) is a benzyl-isoquinoline alkaloid discovered in 1930 as an antitussive agent. Recently, NSC has also been reported to exhibit antitumor activity and, according to computational studies, it is able to ...
Palumbo, Fabrizio; Bosca Mayans, Francisco; Morera Bertomeu, Isabel María; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(Beilstein-Institut, 2016-06-14)
Cholesterol (Ch) is an important lipidic building block and a target for oxidative degradation, which can be induced via free radicals or singlet oxygen (1O2). Suprofen (SP) is a nonsteroidal anti-inflammatory drug that ...
Vendrell Criado, Victoria; Lhiaubet, Virginie Lyria; Yamaji, Minoru; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2016)
The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude. This could to be partially related to the steric hindrance ...
Limones Herrero, Daniel; Pérez Ruiz, Raul; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013)
Reductive photodehalogenation of chloroaromatics is assumed to proceed from the triplet excited state, although its energy is often insufficient to promote a clean homolytic C¿Cl cleavage. A clear-cut experimental proof ...
Bartovsky ., Pavel(Universitat Politècnica de València, 2011-09-30)
Los bencimidazoles se usan como antihelmínticos, antinématodos y antiprotozoos. La colchicina es un alcaloíde tricíclico de orígen natural. Se ha usado en el tratamiento de gota, reumatismo y fiebre mediterránea. Recientemente, ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2020-12-04)
[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Tormos Faus, Rosa Esperanza; Vayá Pérez, Ignacio(The Royal Society of Chemistry, 2004)
[EN] The photophysical properties of S-flurbiprofen [S-2-fluoro-alpha-methyl-4-biphenylacetic acid], a nonsteroidal anti-inflammatory drug, have been examined using steady-state and time-resolved spectroscopic techniques. ...
Reid, Lara O.; Dántola, M. Laura; Petroselli, Gabriela; Erra-Balsells, Rosa; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Thomas, Andrés H.(American Chemical Society, 2019-11)
[EN] The main goal of the present work was to investigate the damages photoinduced by pterin (Ptr), an endogenous photosensitizer present in human skin under pathological conditions, on a globular protein such as ubiquitin ...
Pérez Ruiz, Raúl(Universitat Politècnica de València, 2008-05-07)
La ciclorreversión (CR) oxidativa ó reductiva de oxetanos por transferencia electrónica fotoinducida (TEF), no ha sido estudiada en profundidad, a pesar de que este proceso ha despertado un gran interés en la última década ...
Nuin Pla, Neus Edurne; Sastre Navarro, German Ignacio; Pischel, Uwe; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2015)
[EN] Novel diastereomeric triads containing two naphthalene chromophores have been designed in which an electron-donating amine moiety is covalently integrated into the connecting bridge. Photophysical studies (steady-state ...
Pérez Ruiz, Raul; Sáez Cases, José Antonio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014-11-14)
The radical anions of beta-lactams, photogenerated in the presence of DABCO as an electron donor, undergo cycloreversion via N-C4 bond cleavage, back electron transfer and final C2-C3 bond cleavage, leading to olefins. The ...
Gómez Mendoza, Miguel; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-03-15)
Three ¿uorescent cholic acid derivatives incorporating the dansyl chromophore at positions 3R, 3ß, and 7Rhave been successfully employed to build the speciation
diagram of sodium cholate by means of steady-state and ...
Rohacova, Jana; Sastre Navarro, German Ignacio; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-09-08)
[EN] Binding of natural bile acids to human serum albumin (HSA) is an important step in enterohepatic circulation and provides a measure of liver function. In this article, we report on the use of four dansyl (Dns) derivatives ...
Gómez Mendoza, Miguel; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012-12-27)
Bile acids (BAs) are a family of natural steroids biosynthesized from cholesterol in the liver that tend to form aggregates in solution. A fluorescent derivative of cholic acid, namely 3 alpha-Dns-ChA, was employed as a ...
Pavanello, Alice; Gomez-Mendoza, Miguel; de la Peña O'Shea, Víctor; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa(Elsevier, 2022-04)
[EN] Benzotriazole UV-stabilizers (BUVSs) are commonly used in industry as solar filters, due to their strong UV light absorption. Because of their extended usage, environmental contamination of waters due to BUVSs constitutes ...
Domingo, Luis R.; Pérez Ruiz, Raúl; Arguello, Juan Elias; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-06)
The molecular mechanism of the cycloreversion (CR) of thietane radical cations has been analyzed in detail at the UB3LYP/6-31G* level of theory. Results have shown that the process takes place via a stepwise mechanism ...
Abad Fuentes, Sergio; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Pischel ., Uwe; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2006)
[EN] Four new bichromophoric naphthalene dyads in form of diastereomeric pairs are synthesized and photophysically characterized. For a closely related group of compounds (NAP-NAP MNAP-NAP, MNAP-MNAP), systematic variation ...
Martínez-Haya, Rebeca; Gomis Vicens, Juan; Arqués Sanz, Antonio; Amat Payá, Ana María; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa(Elsevier, 2018-08-15)
[EN] Advanced oxidation processes are useful methodologies to accomplish abatement of contaminants; however, elucidation of the reaction mechanisms is hampered by the difficult detection of the short-lived primary key ...
Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel; Bosca Mayans, Francisco(The Royal Society of Chemistry, 2017)
[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in ...