Estébanez, Sandra; Rivera, Ana M.; Recky, Jael R. Neyra; Thomas, Andres H.; Lhiaubet, Virginie Lyria; Lorente, Carolina(Elsevier, 2021-10)
[EN] Pterin (Ptr) is a model photosensitizer that acts mainly through type I mechanism and is able to photoinduce the one-electron oxidation of purine and pyrimidine nucleobases. However, under anaerobic conditions Ptr ...
Rodríguez Muñiz, Gemma María; Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(Wiley-VCH Verlag, 2012-06-25)
DNA damage: The reactivity of HO. with silylated 2¿-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported ...
Fraga Timiraos, Ana Belén; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(Wiley, 2016-05-10)
[EN] Photolyases are intriguing enzymes that take advantage of sunlight to restore lesions like cyclobutane pyrimidine dimers or (6-4) photoproducts. This work focused on the photoreductive process responsible for splitting ...
Marín Melchor, Mireia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-03-08)
[EN] : In the present work, the in¿uence of serum albumins as biological
hosts on the well-established photo-Fries rearrangement has been investigated. For this purpose,
4-methoxy-1-naphthyl hydrogen succinate and ...
Lammers, Ivonne; Lhiaubet, Virginie Lyria; Jiménez Molero, María Consuelo; Ariese, Freek; Miranda Alonso, Miguel Ángel; Gooijer, Cees(Wiley, 2012-10)
The interaction of the nonsteroidal anti-inflammatory drug flurbiprofen (FBP) with human serum albumin (HSA) hardly influences the fluorescence of the protein's single tryptophan (Trp). Therefore, in addition to fluorescence, ...
Fraga-Timiraos, Ana Belén; Rodríguez Muñiz, Gemma María; Peiro-Penalba, Vicente; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(MDPI AG, 2016-12)
[EN] Electron transfer involving nucleic acids and their derivatives is an important field in bioorganic chemistry, specifically in connection with its role in the photo-driven DNA damage and repair. Four-membered ring ...
Aparici-Espert, Maria Isabel; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(MDPI AG, 2018-03)
[EN] Photosensitization by drugs is a problem of increasing importance in modern life. This phenomenon occurs when a chemical substance in the skin is exposed to sunlight. Photosensitizing drugs are reported to cause severe ...
Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2016)
[EN] Based on our previous investigations into the photophysical properties of the 5-methyl-2-pyrimidone (Pyo) chromophore, we now extend our studies to the photobehavior of the dimeric (6-4) thymine photoproducts (6-4 PP) ...
Lizondo-Aranda, Paloma; Martínez-Fernández, Lara; Miranda Alonso, Miguel Ángel; Improta, Roberto; Gustavsson, Thomas; Lhiaubet, Virginie Lyria(American Chemical Society, 2022-01-13)
[EN] Joint femtosecond fluorescence upconversion experiments and theoretical calculations provide a hitherto unattained degree of characterization and understanding of the mutagenic etheno adduct 3,N4-etheno-2'-deoxycytidine ...
Navarrete-Miguel, Miriam; Francés-Monerris, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Roca-Sanjuan, Daniel(MDPI AG, 2021-05)
[EN] Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) ...
Francés-Monerris, Antonio; Hognon, Cécilia; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Monari, Antonio(The Royal Society of Chemistry, 2018-10-28)
[EN] Nucleic acids are constantly exposed to external agents that can induce chemical and photochemical damage. In spite of the great advances achieved in the last years, some molecular mechanisms of DNA damage are not ...
Lineros-Rosa, Mauricio; Cuquerella Alabort, Maria Consuelo; Francés-Monerris, Antonio; Monari, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(The Royal Society of Chemistry, 2021-04-28)
[EN] Recently, sunscreen-based drug photocages have been introduced to provide UV protection to photoactive drugs, thus increasing their photosafety. Here, combined experimental and theoretical studies performed on a ...
Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Yamaji, Minoru; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-11-06)
Photolysis of the benzophenone chromophore by means of high energy laser pulses has been used as a tool to populate upper thymine-like triplet states via intramolecular sensitization. These species undergo characteristic ...