Jornet Olivé, Mª Dolors; Bosca Mayans, Francisco; Andreu, Jose Maria; Domingo, L.R.; Tormos Faus, Rosa Esperanza; Miranda Alonso, Miguel Ángel(Elsevier, 2016-02)
[EN] Mebendazole (MBZ) and related anticancer benzimidazoles act binding the beta-subunit of Tubulin (TU) before dimerization with alpha-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2020-12-04)
[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Bosca Mayans, Francisco; Sastre Navarro, German Ignacio; Andreu, José María; Jornet, David; Tormos Faus, Rosa Esperanza; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2015)
[EN] Colchicine (COL) is a bioactive molecule with antitumor properties. When COL binds to tubulin (TU), it inhibits microtubule assembly dynamics. We have investigated COL-TU interactions using laser flash photolysis (LFP) ...