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Mostrando ítems 1-4 de 4

Analysis of mebendazole binding to its target biomolecule by laser flash photolysis

Jornet Olivé, Mª Dolors; Bosca Mayans, Francisco; Andreu, Jose Maria; Domingo, L.R.; Tormos Faus, Rosa Esperanza; Miranda Alonso, Miguel Ángel (Elsevier, 2016-02)

[EN] Mebendazole (MBZ) and related anticancer benzimidazoles act binding the beta-subunit of Tubulin (TU) before dimerization with alpha-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a ...
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies

Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Cuquerella Alabort, Maria Consuelo; Navarrete-Miguel, Miriam; Roca-Sanjuán, Daniel; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2020-12-04)

[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and ...
Drug-tubulin interactions interrogated by transient absorption spectroscopy

Bosca Mayans, Francisco; Sastre Navarro, German Ignacio; Andreu, José María; Jornet, David; Tormos Faus, Rosa Esperanza; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2015)

[EN] Colchicine (COL) is a bioactive molecule with antitumor properties. When COL binds to tubulin (TU), it inhibits microtubule assembly dynamics. We have investigated COL-TU interactions using laser flash photolysis (LFP) ...
Modulation of the photobehavior of gefitinib and its phenolic metabolites by human transport proteins

Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Miranda Alonso, Miguel Ángel; Vayá Pérez, Ignacio (Frontiers Media SA, 2024-05-16)

[EN] The photobiological damage that certain drugs or their metabolites can photosensitize in proteins is generally associated with the nature of the excited species that are generated upon interaction with UVA light. In ...

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Listar por palabra clave "Anticancer drugs"

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