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Listar por palabra clave "Biodistribution"

Mostrando ítems 1-6 de 6

Biosafety of mesoporous silica nanoparticles; towards clinical translation

Lérida-Viso, Araceli; Estepa-Fernández, Alejandra; García-Fernández, Alba; Martí-Centelles, Vicente; Martínez-Máñez, Ramón (Elsevier, 2023-10)

[EN] Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who have developed numerous systems for the encapsulation of a plethora of molecules, allowing the use of mesoporous silica nanoparticles ...
Effect of obesity on biodistribution of nanoparticles

Felismino, Claudiana de Jesus; Helal-Neto, E.; Portilho, F.L.; Rocha Pinto, Suyene; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Ferreira, Agatha de Assis; da Silva, Simone Vargas; Barja-Fidalgo, Thereza Christina; Santos-Oliveira, Ralph (Elsevier, 2018-07-10)

[EN] Nanoparticles have specific features (lipophilicity, surface charge, composition and size). Studies regarding the biological behavior of nanoparticles in diseases such diabetics and obesity are scarce. Here, we evaluated ...
Effect of surface properties in protein corona development on mesoporous silica nanoparticles

CLEMMENTS, ALDEN MICHAEL; Muniesa Lajara, Carlos; Landry, Christopher Caron; Botella Asuncion, Pablo (Royal Society of Chemistry, 2014)

[EN] The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized. Low MW serum proteins were preferentially adsorbed, and PEGylated nanoparticles did ...
Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs

Di Meo, Chiara; Martínez Martínez, Mayte; Coviello, Tommasina; Bermejo, M.; Merino Sanjuán, Virginia; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Matricardi, P. (MDPI AG, 2018-11-03)

[EN] Nanohydrogels based on natural polymers, such as polysaccharides, are gaining interest as vehicles for therapeutic agents, as they can modify the pharmacokinetics and pharmacodynamics of the carried drugs. In this ...
Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals

Rezende dos Reis, Sara Rhaissa; Rocha Pinto, Suyene; Duarte de Menezes, Frederico; Martínez-Máñez, Ramón; Ricci-Junior, Eduardo; Rebelo Alencar, Luciana Magalhaes; Helal-Neto, Edward; Da Silva De Barros, Aline Oliveira; Lisboa, Patricia Cristina; Santos-Oliveira, Ralph (Springer-Verlag, 2020-01-22)

[EN] Purposes Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies ...
Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

Botella Asuncion, Pablo; Abasolo, Ibane; Fernández, Yolanda; Muniesa Lajara, Carlos; Miranda, Sonia; Quesada Vilar, Manuel; Ruiz Carrascal, Jorge; Schwart, Simó; Corma Canós, Avelino (Elsevier, 2011)

[EN] Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle through an ester ...