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Listar por palabra clave "Camptothecin"

Mostrando ítems 1-11 de 11

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability

Rodríguez Berna, Guillermo; Mangas Sanjuan, Victor; Gonzalez Alvarez, Marta; Gonzalez Álvarez, Isabel; Garcia Gimenez, Jose Luis; Díaz Cabañas, Mª José; Bermejo, Marival; Corma Canós, Avelino (Elsevier, 2014-08-18)

Oral administration of camptothecin (Cm) derivatives and other antitumoral agents is being actively developed in order to improve the quality of life of patients with cancer. Though several lipophilic derivatives of CPT ...
Amidase-responsive controlled release of antitumoral drug into intracellular media using gluconamide-capped mesoporous silica nanoparticles

Candel Busquets, Inmaculada; Aznar Gimeno, Elena; Mondragón Martínez, Laura; De la Torre Paredes, Cristina; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Amoros del Toro, Pedro Jose; Guillem, Carmen; Pérez Payá, Enrique; Costero Nieto, Ana María; Gil Grau, Salvador; Parra Álvarez, Margarita (Royal Society of Chemistry, 2012-10-02)

MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of ...
Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Cabrera-García, Alejandro; Checa-Chavarria, Elisa; Rivero-Buceta, Eva María; MORENO MANZANO, VICTORIA; FERNANDEZ JOVER, EDUARDO; BOTELLA ASUNCION, PABLO (Elsevier, 2019-04-01)

[EN] MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore ...
Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

Martínez-Martínez, M.; Rodríguez Berna, Guillermo; Bermejo, Marival; Gonzalez-Alvarez, Isabel; Gonzalez -Alvarez, Marta; Merino, Virginia (Elsevier, 2019-03)

[EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...
Development of a Prodrug of Camptothecin for Enhanced Treatment of Glioblastoma Multiforme

Checa-Chavarria, Elisa; Rivero-Buceta, Eva María; Sanchez Martos, Miguel Angel; Martinez Navarrete, Gema; Soto-Sanchez, Cristina; BOTELLA ASUNCION, PABLO; FERNANDEZ JOVER, EDUARDO (American Chemical Society, 2021-04-05)

[EN] A novel therapeutic approach for glioblastoma multiforme (GBM) therapy has been carried out through in vitro and in vivo testing by using the prodrug camptothecin-20-O-(5-aminolevulinate) (CPT-ALA). The incorporation ...
Efecto de las condiciones de cultivo en los programas de apoptosis intrínseco y extrínseco.

Martín Sabuco, Álvaro (Universitat Politècnica de València, 2021-07-08)

[ES] La investigación en el descubrimiento y mejora de nuevas terapias anticancerígenas ha sido y es uno de los ámbitos más importantes en la investigación biomédica. Dentro de la gama de tratamientos actuales uno de los ...
Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels

Macchione, Micaela A.; Aristizábal Bedoya, Dariana; Rivero-Buceta, Eva María; BOTELLA ASUNCION, PABLO; Strumia, Miriam C. (MDPI AG, 2022-11)

[EN] Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic ...
Nanomedicinas para terapia dirigida de glioblastoma multiforme

Alemany Ibor, Laura (Universitat Politècnica de València, 2021-07-30)

[ES] Glioblastoma multiforme (GBM) es el tumor cerebral más agresivo y letal conocido, con una media de supervivencia de 15 meses desde el diagnóstico inicial. Actualmente no existe un tratamiento farmacológico efectivo ...
Sequential pore wall functionalization in covalent organic frameworks and application to stable camptothecin delivery systems

De Santana Oliveira, Artur; Rivero-Buceta, Eva María; Vidaurre-Agut, Carla; Misturini, Alechania; Moreno, Victoria; Jorda Moret, Jose Luis; SASTRE NAVARRO, GERMAN IGNACIO; Castella Pergher, Sibele Berenice; BOTELLA ASUNCION, PABLO (Elsevier, 2020-12)

[EN] Post-synthetic modification of covalent organic frameworks (COFs) is strongly demanded in order to provide additional functionalities to their structures. However, the introduction of functional groups during the ...
Silica-Based Stimuli-Responsive Systems for Antitumor Drug Delivery and Controlled Release

Corma Canós, Avelino; BOTELLA ASUNCION, PABLO; Rivero-Buceta, Eva María (MDPI AG, 2022-01)

[EN] The administration of cytotoxic drugs in classical chemotherapy is frequently limited by water solubility, low plasmatic stability, and a myriad of secondary effects associated with their diffusion to healthy tissue. ...
Surface-modified silica nanoparticles for tumor-targeted delivery of camptothecin and its biological evaluation

Botella Asuncion, Pablo; Abasolo, Ibane; Fernández, Yolanda; Muniesa Lajara, Carlos; Miranda, Sonia; Quesada Vilar, Manuel; Ruiz Carrascal, Jorge; Schwart, Simó; Corma Canós, Avelino (Elsevier, 2011)

[EN] Here we report the design, synthesis and biological evaluation of surface-modified silica nanoparticles (SNP) for the delivery of camptothecin (CPT). Drug has been covalently linked to the nanoparticle through an ester ...