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Listar por palabra clave "Cardiac safety"

Mostrando ítems 1-5 de 5

Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Llopis-Lorente, Jordi; Baroudi, Samuel; Koloskoff, Kévin; Mora-Fenoll, María Teresa; Basset, Matthieu; Romero Pérez, Lucia; Benito, Sylvain; Dayan, Frederic; Saiz Rodríguez, Francisco Javier; Trenor Gomis, Beatriz Ana (Elsevier, 2023-12)

[EN] Background and Objective: In silico methods are gaining attention for predicting drug-induced Torsade de Pointes (TdP) in different stages of drug development. However, many computational models tended not to account ...
Combining pharmacokinetic and electrophysiological models for early prediction of drug-induced arrhythmogenicity

Llopis-Lorente, Jordi; Baroudi, Samuel; Koloskoff, Kévin; Romero Pérez, Lucia; Mora-Fenoll, María Teresa; Basset, Matthieu; Benito, Sylvain; Dayan, Frederic; Saiz Rodríguez, Francisco Javier; Trénor Gomis, Beatriz Ana (Universitat Politècnica de València, 2023-03-29)

This repository contains the code used to generate the male and female population of models and simulate the different pharmacokinetic scenarios in Llopis-Lorente et al. (2023). Combining pharmacokinetic and electrophysiological ...
Considering population variability of electrophysiological models improves the assessment of drug-induced torsadogenic risk

Llopis-Lorente, Jordi; Trenor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier (Elsevier, 2022-06)

[EN] Background and Objective In silico tools are known to aid in drug cardiotoxicity assessment. However, computational models do not usually consider electrophysiological variability, which may be crucial when predicting ...
Considering Population Variability of Electrophysiological Models Improves the In Silico Assessment of Drug-Induced Torsadogenic Risk

Llopis Lorente, Jordi; Trénor Gomis, Beatriz Ana; Saiz Rodríguez, Francisco Javier (2022-05-13)

This repository contains the parameter sets of the population of TorORd models and the the population of ORdmD models, the ORdmD CellML file and MALTAB code used in Llopis-Lorente, J., Trenor, B., Saiz, J. (2022). Considering ...
Uncertainty Assessment of Proarrhythmia Predictions Derived from Multi-Level in Silico Models

Kopanska, Karolina; Rodríguez-Belenguer, Pablo; Llopis-Lorente, Jordi; Trénor, Beatriz; Saiz, Javier; Pastor, Manuel (Universitat Politècnica de València, 2023-02-14)

[EN] These datasets were generated to train ("PopulationDrugsTrainingKrNaLCaL.xlsx") and test ("PopulationDrugsTestKrCaLNaL.xlsx") the uncertainty assessment models developed in the paper "Uncertainty assessment of ...

Mostrando ítems 1-5 de 5

Listar por palabra clave "Cardiac safety"

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