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Listar por palabra clave "Cellular senescence"

Mostrando ítems 1-5 de 5

Chromo-fluorogenic probes for beta-galactosidase detection

Lozano-Torres, Beatriz; Blandez, Juan F.; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Springer-Verlag, 2021-02-19)

[EN] beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides. beta-Gal is an essential enzyme in humans and its ...
Desarrollo de nanodispositivos terapéuticos aplicados a enfermedades relacionadas con procesos de senescencia

Galiana Guillem, Irene (Universitat Politècnica de València, 2016-05-25)

[EN] The main goal of the current project is the design and synthesis of new nanomaterials for the detection and elimination of senescent cells, focused on the treatment of senescence-related diseases such as idiopathic ...
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González-Gualda, Estela; Pàez-Rives, Marta; Lozano-Torres, Beatriz; Macias, David; Wilson III, Joseph R.; González-López, Cristina; Ou, Hui-Ling; MIrón-Barroso, Sofía; Zhang, Zhenguang; Lérida-Viso, Araceli; Blandez, Juan F.; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Rovira, Miguel; Fruk, Ljiljana; Martins, Carla P.; Serrano, Manuel; Doherty, Gary J.; Martínez-Máñez, Ramón; Muñoz-Espín, Daniel (Blackwell Publishing, 2020-04)

[EN] Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse ...
Lipofuscin labeling through biorthogonal strain-promoted azide-alkyne cycloaddition for the detection of senescent cells

Lozano-Torres, Beatriz; Blandez, Juan F.; García-Fernández, Alba; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Blackwell Publishing, 2023-03)

[EN] A new method for senescent cell detection is described, which is based on lipofuscin labeling with a fluorescent reporter through a biorthogonal strain-promoted azide-alkyne cycloaddition. The sensing protocol involves ...
Novel probes, carriers and prodrugs to target senescent cells in vivo

Lozano Torres, Beatriz (Universitat Politècnica de València, 2021-09-02)

[ES] La presente tesis doctoral titulada "Nuevas sondas, portadores y pro-fármacos dirigidos a células senescentes in vivo" se centra en el diseño, preparación, caracterización y evaluación de sondas basadas en fluoróforos ...