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Mostrando ítems 1-5 de 5

Assessment of the genotoxic and mutagenic effects induced by T-2 mycotoxin in HepG2 cells

Taroncher, Mercedes; Fuentes López, Cristina; Rodríguez-Carrasco, Yelko; Ruiz, María-José (Elsevier Ireland Ltd., 2024-01)

[EN] The T-2 toxin is a mycotoxin produced by molds belonging to Fusarium. Among the Fusarium mycotoxins, trichothecenes are frequently reported in food and feed, being the T-2 toxin (T-2) the mycotoxin which possesses the ...
Assessment of the PARP inhibitor talazoparib photosafety profile

Mateos-Pujante, Alejandro; Jiménez, M Consuelo; Andreu, Inmaculada (Elsevier, 2023-11)

[EN] Talazoparib (TLZ) is a poly(adenosine diphosphate [ADP]-ribose) polymerase inhibitor employed for the treatment of breast cancer. This drug displays an absorption band in the UVA region, and therefore investigation ...
Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

Palumbo, Fabrizio; García Lainez, Guillermo; Limones Herrero, Daniel; Coloma, María Dolores; Escobar, Javier; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2016)

Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...
Evaluación de la fotoestabilidad y la foto(geno)toxicidad in vitro del fármaco simeprevir

Moreno Muñoz, Alejandro (Universitat Politècnica de València, 2018-09-18)

[ES] El fármaco simeprevir (SIM) se utiliza en el tratamiento de la infección crónica por el virus de la hepatitis C (VHC), principalmente el genotipo 1, formando parte de una terapia antiviral combinada con otros fármacos. ...
Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

García -Laínez, Guillermo; Ana M Marínez-Reig; Limones Herrero, Daniel; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Elsevier, 2018)

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order ...

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