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Listar por palabra clave "DNA damage"

Mostrando ítems 1-19 de 19

Caracterización molecular de modelos celulares asociados a tres genotipos de la Disqueratosis Congénita

Fuster Martí, Vanessa (Universitat Politècnica de València, 2016-09-05)

[ES] La Disqueratosis congénita (DC, ORPHA1775) está catalogada como una enfermedad rara, con una prevalencia 1 en 1.000.000. Se trata de una enfermedad progeroide que presenta una clásica triada de signos mococutaneos: ...
EFFECTS OF GLUTATHIONE LEVELS ON DNA DAMAGE

Spis, Marta (Universitat Politècnica de València, 2011-09-21)

Free radicals cause DNA damage known as double-strand breaks (DSBs). In response to these DSBs phosphorylation of histone H2AX occurs. yH2AX foci are trademarks of DSBs. We evaluated the levels of yH2AX in relation to ...
eIF2 kinases mediate beta-lapachone toxicity in yeast and human cancer cells

MENACHO MARQUEZ, Mauricio Ariel; Rodríguez Hernández, Carlos Javier; Villaronga, Ángeles; Pérez Valle, Jorge; Gadea Vacas, José; Belandia, Borja; Murguía Ibáñez, José Ramón (Taylor & Francis, 2015-03)

[EN] In this work we focus on the problem of approximating multiple roots of nonlinear equations. Multiple roots appear in some applications such as the compression of band-limited signals and the multipactor effect in ...
Evaluación del potencial fotoquímico y fotobiológico de los inhibidores de la poli (ADP-ribosa) polimerasa

Mateos Pujante, Alejandro (Universitat Politècnica de València, 2023-09-07)

[ES] En la presente tesis doctoral se ha desarrollado una metodología multidisciplinar para la evaluación del potencial fotoquímico y fotobiológico in vitro de los fármacos inhibidores de la poli (ADP-ribosa) polimerasa ...
Fotorreparación de lesiones del ADN por sistemas modelo

Piñero Piquer, Enrique (Universitat Politècnica de València, 2022-07-18)

[ES] La peroxidación lipídica es un proceso biológico que ocurre ininterrumpidamenteen nuestro cuerpo como resultado de la oxidación de la membrana celular por especies reactivas de oxígeno (EROs). La degradación de los ...
Generation of the Thymine Triplet State by Through-Bond Energy Transfer

Miró, Paula; Gomez-Mendoza, Miguel; SASTRE NAVARRO, GERMAN IGNACIO; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa (John Wiley & Sons, 2019-05-17)

[EN] Benzophenone (BP) and drugs containing the BP chromophore, such as the non-steroidal anti-inflammatory drug ketoprofen, have been widely reported as DNA photo-sensitizers through triplet-triplet energy transfer (TTET). ...
In vitro assessment of the photo(geno)toxicity associated with Lapatinib, a Tyrosine Kinase inhibitor

García-Laínez, G.; Vayá Pérez, Ignacio; Marín, Mª Pilar; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada (Springer-Verlag, 2021-01)

[EN] The epidermal growth factor receptors EGFR and HER2 are the main targets for tyrosine kinase inhibitors (TKIs). The quinazoline derivative lapatinib (LAP) is used since 2007 as dual TKI in the treatment of metastatic ...
In Vitro Photobehavior of Tyrosine Kinase Inhibitors in Solution and within Skin Cells

Ouardi el Hamidy, Meryem el (Universitat Politècnica de València, 2024-07-11)

[ES] En las últimas décadas, la aprobación de los inhibidores de la tirosina quinasa (del inglés TKI) como una nueva clase de terapia dirigida ha mejorado la calidad de vida y las tasas de supervivencia de los pacientes ...
Mechanistic Studies on the Photochemical Formation and Cleavage of Oxetanes Derived from Pyrimidine Bases

Blasco Brusola, Alejandro (Universitat Politècnica de València, 2021-04-13)

[ES] La luz solar puede producir daños en el ADN por absorción directa de luz UVB, o por fotosensibilización tras la absorción de luz UVA por parte de fármacos, que pueden actuar como fotosensibilizadores (PS). La benzofenona ...
Photoreactivity of DNA Etheno Adducts: Spectroscopic and Mechanistic Study

Lizondo Aranda, Paloma (Universitat Politècnica de València, 2022-11-14)

[ES] Los estudios sobre los daños en el ADN se han incrementado en las últimas décadas con el fin de profundizar en su implicación en la aparición del cáncer. Entre el gran número de lesiones del ADN, los aductos de tipo ...
Photosensitization of DNA by 5-methyl-2pyrimidone deoxyribonucleoside: (6-4) photoproduct as a posible trojan horse

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley-VCH Verlag, 2013-06-17)

A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These ...
Photosensitized Thymine Dimerization via Delocalized Triplet Excited States

Miró Richart, Paula; Lhiaubet, Virginie Lyria; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel (Wiley, 2015-11-16)

A new mechanism of photosensitized formation of thymine (Thy) dimers is proposed, which involves generation of a delocalized triplet excited state as the key step. This is supported by chemical evidence obtained by combining ...
Reactivity of Nucleosides with a Hydroxyl Radical in Non-aqueous Medium

Rodríguez Muñiz, Gemma María; Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley-VCH Verlag, 2012-06-25)

DNA damage: The reactivity of HO. with silylated 2¿-deoxyribonucleosides was investigated in acetonitrile by means of a time-resolved technique. The obtained rate constants were in general slightly lower than those reported ...
Repair of a Dimeric Azetidine Related to the Thymine-Cytosine (6-4) Photoproduct by Electron Transfer Photoreduction

Fraga Timiraos, Ana Belén; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (Wiley, 2016-05-10)

[EN] Photolyases are intriguing enzymes that take advantage of sunlight to restore lesions like cyclobutane pyrimidine dimers or (6-4) photoproducts. This work focused on the photoreductive process responsible for splitting ...
Sodium tungstate modulates ATM function upon DNA damage

Rodríguez Hernández, Carlos Javier; Llorens Agost, M.; Calbó, J.; Murguía, Jose R.; Guinovart, J.J. (Wiley, 2013-05-21)

[EN] Both radiotherapy and most effective chemotherapeutic agents induce different types of DNA damage. Here we show that tungstate modulates cell response to DNA damaging agents. Cells treated with tungstate were more ...
The (6-4) Dimeric Lesion as a DNA Photosensitizer

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2016)

[EN] Based on our previous investigations into the photophysical properties of the 5-methyl-2-pyrimidone (Pyo) chromophore, we now extend our studies to the photobehavior of the dimeric (6-4) thymine photoproducts (6-4 PP) ...
The Excited State Dynamics of a Mutagenic Guanosine Etheno Adduct Investigated by Femtosecond Fluorescence Spectroscopy and Quantum Mechanical Calculations

Lizondo-Aranda, Paloma; Gustavsson, Thomas; Martinez-Fernández, Lara; Improta, Roberto; Lhiaubet, Virginie Lyria (John Wiley & Sons, 2024-09-02)

[EN] Femtosecond fluorescence upconversion experiments were combined with CASPT2 and time dependent DFT calculations to characterize the excited state dynamics of the mutagenic etheno adduct 1,N2-etheno-2'-deoxyguanosine ...
Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser

Rodriguez-Alzueta, Ofelia; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Elsevier, 2019-07-05)

[EN] 2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting ...
Un enfoque de biología de sistemas para integrar la investigación sobre los mecanismos moleculares, celulares y tisulares del daño del ADN para mejorar la predicción del riesgo de cáncer.

Martínez Santa, Marta (Universitat Politècnica de València, 2021-01-19)

[ES] Existe un reconocimiento creciente de que el cáncer como enfermedad es el resultado de un fallo sistémico en el cual muchas células, además de aquellas con genomas oncogénicos, determinan la frecuencia de cáncer. Se ...