[EN] Epigenetic alterations have an important role in the development of several types of cancer. Epigenetic studies generate a large amount of data, which makes it essential to develop novel models capable of dealing with ...
Martínez Arias, Germán Eugenio; Castellano Pérez, Mayte; Tortosa-Viqueira, Maria; Pallás Benet, Vicente; Gomez, Gustavo Germán(Oxford University Press (OUP), 2014-02)
[EN] Viroids are plant-pathogenic non-coding RNAs able to interfere with as yet poorly known host-regulatory pathways and to cause alterations recognized as diseases. The way in which these RNAs coerce the host to express ...
[EN] Viroids - ancient plant-pathogenic long noncoding RNAs - have developed a singular evolutionary strategy based on reprogramming specific phases of host-metabolism to ensure that their infection cycle can be completed ...
Gómez López, Francisco José(Universitat Politècnica de València, 2019-09-05)
[ES] Las plantas presentan una serie de mecanismos de adaptación y supervivencia que les ha permitido
hacer frente a distintas condiciones medioambientales adversas que actúan como inductoras del
estrés. La estabilidad ...
[EN] Early alterations in cancer include the deregulation of epigenetic events such as changes in DNA methylation and abnormal levels of non-coding (nc)RNAs. Although these changes can be identified in tumors, alternative ...
[EN] The critical situation of the European eel (Anguilla anguilla) has urged the development of sperm cryopreservation protocols for reproduction in captivity and cryobanking. In the last years, two research groups have ...
Del Amor del Amor, María Rocío(Universitat Politècnica de València, 2021-01-26)
[ES] El cáncer de piel representa el grupo más común de neoplasias malignas en la población blanca. De hecho, en la actualidad, uno de cada tres cánceres diagnosticados es cáncer de piel. Aunque dos de los cánceres cutáneos ...
[EN] DNA methylation is an epigenetic mark that regulates multiple processes, such as gene expression and genome stability. Mutants and pharmacological treatments have been instrumental in the study of this mark in plants, ...
Ausin, Israel; Feng, Suhua; Yu, Chaowei; Liu, Wanlu; Kuo, Hsuan Yu; Jacobsen, Elise L.; Zhai, Jixian; Gallego Bartolomé, Javier; Wang, Lin; Egertsdotter, Ulrika; Street, Nathaniel R.; Jacobsen, Steven E.; Wang, Haifeng(Proceedings of the National Academy of Sciences, 2016-12-13)
[EN] DNA methylation plays important roles in many biological processes, such as silencing of transposable elements, imprinting, and regulating gene expression. Many studies of DNA methylation have shown its essential roles ...
[EN] Embryo manipulation is a requisite step in assisted reproductive technology (ART). Therefore, it is of great necessity to appraise the safety of ART and investigate the long-term effect, including lipid metabolism, ...
[EN] DNA cytosine methylation is one of the main epigenetic mechanisms in higher eukaryotes
and is considered to play a key role in transcriptional gene silencing. In plants, cytosine methylation can
occur in all sequence ...
Lin Wong, Liliane(Universitat Politècnica de València, 2020-10-07)
[ES] La miocardiopatía arritmogénica (MCA) es una enfermedad genética rara (OMIM #107970; ORPHA247) con una prevalencia de entre 1:1000 y 1:5000. Se caracteriza por la sustitución progresiva del miocardio por tejido ...
González, Beatriz; Vera Vera, Pablo(Elsevier, 2019-09-02)
[EN] Plants rely on primary metabolism for flexible adaptation to environmental changes. Here, through a combination of chemical genetics and forward genetic studies in Arabidopsis plants, we identified that the essential ...
[EN] Epigenetics, a potential underlying pathogenic mechanism of neurodegenerative diseases, has been in the scope of several studies performed so far. However, there is a gap in regard to analyzing different forms of ...
Trinidad, Eva María; Vidal, Enrique; Coronado, Ester; Esteve-Codina, Anna; Castel, Victoria; Cañete, Adela; Gut, Marta; Heath, Simon; Font de Mora, Jaime(Oxford University Press, 2023-01)
[EN] Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping and prognosis. However, its application is frequently hampered by ...
Candela-Ferre, Joan; Diego-Martín, Borja; Pérez-Alemany, Jaime; Gallego-Bartolomé, Javier(American Society of Plant Biologists, 2024-03-29)
[EN] Chromatin plays a crucial role in genome compaction and is fundamental for regulating multiple nuclear processes. Nucleosomes, the basic building blocks of chromatin, are central in regulating these processes, determining ...
Torres-Ruiz, Sandra; Garrido-Cano, Iris; Lameirinhas, Ana; Burgués, Octavio; Hernando, Cristina; Martínez, Maria Teresa; Rojo, Federico; Bermejo, Begoña; Tapia, Marta; Carbonell-Asins, Juan Antonio; Peña, Carlos Javier; Lluch, Ana; Cejalvo, Juan Miguel; Tormo, Eduardo; Eroles, Pilar(2024-08-22)
[EN] Despite progress in breast cancer treatment, a significant portion of patients still relapse because of drug resistance. The involvement of microRNAs in cancer progression and chemotherapy response is well established. ...
Melero Alarte, Vicent(Universitat Politècnica de València, 2020-09-15)
[ES] La enfermedad inflamatoria intestinal abarca un conjunto de patologías inflamatorias de carácter crónico reincidente que envuelve cualquier parte del tracto gastrointestinal. La EII incluye dos trastornos principales, ...
[EN] It is well known that viroids promote significant alterations at diverse host regulatory levels. However the mechanisms by which these tiny RNAs subvert endogenous regulatory networks remain a to a large extent unsolved ...