[EN] Background: Platinum doublets are standard chemotherapy for advanced non-small-cell lung cancer (NSCLC). The aim of this study was to assess whether neutropenia is: (1) an indicator for treatment efficacy, or (2) ...
The majority of non-small-cell lung cancer (NSCLC) patients present with locally advanced (35%) or metastatic disease (40%); in this setting, it is of the utmost importance to balance efficacy with toxicity. However, with ...
Fraga-Timiraos, Ana Belén; Rodríguez Muñiz, Gemma María; Peiro-Penalba, Vicente; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(MDPI AG, 2016-12)
[EN] Electron transfer involving nucleic acids and their derivatives is an important field in bioorganic chemistry, specifically in connection with its role in the photo-driven DNA damage and repair. Four-membered ring ...
Navarrete-Miguel, Miriam; Francés-Monerris, Antonio; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Roca-Sanjuan, Daniel(MDPI AG, 2021-05)
[EN] Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) ...