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Mostrando ítems 1-5 de 5

Establecimiento de una metodología alternativa a la experimentación animal para la evaluación del potencial de sensibilización cutánea de los antineoplásicos Imatinib y Erlotinib

Tomás Martínez, Anaís (Universitat Politècnica de València, 2021-04-08)

[ES] Según la United Nation Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS), se entiende que un compuesto químico es un sensibilizante cutáneo si es capaz de desencadenar una reacción ...
Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

Pucci, M.; Asiain, P.R.; Durendez-Saez, Elena; Jantus-Lewintre, Eloisa; Malarani, M.; Khan, S.; Fontana, S.; Naing, A.; Passiglia, F.; Raez, L.E.; Rolfo, C.; Taverna, S. (Springer-Verlag, 2018-04)

[EN] Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor ...
Material-driven fibronectin fibrillogenesis to engineer cell function

Llopis Hernández, Virginia (Universitat Politècnica de València, 2017-11-03)

This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It ...
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Baldominos, Pilar; Barbera-Mourelle, Alex; Barreiro, Olga; Huang, Yu; Wight, Andrew; Cho, Jae-Won; Zhao, Xi; Estivill, Guillem; Adam, Isam; Sanchez, Xavier; McCarthy, Shannon; Schaller, Julien; Khan, Zara; Ruzo, Albert; Agudo, Judith (Elsevier, 2022-05-12)

[EN] Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of resistance. We discovered that in primary breast cancer, ...
Semisynthetic Abietic and Dehydroabietic Acid Derivatives and Triptoquinone Epimers Interfere with LPS-Triggered Activation of Dendritic Cells

Sierra, Jelver A.; Gilchrist, Katherine; Tabares-Guevara, Jorge H.; Betancur-Galvis, Liliana; Ramírez-Pineda, José R.; González-Cardenete, Miguel A (MDPI AG, 2022-10)

[EN] Abietic acid (AA), dehydroabietic acid (DHA) and triptoquinones (TQs) are bioactive abietane-type diterpenoids, which are present in many edible vegetables and medicinal herbs with health-promoting properties. Evidence ...

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