[EN] A novel methodology is proposed for defining multivariate raw material specifications providing assurance of quality with a certain confidence level for the critical to quality attributes (CQA) of the manufactured ...
[EN] The Sequential Multi-Block Partial Least Squares (SMB-PLS) model inversion is applied for defining analytically the multivariate raw material region providing assurance of quality with a certain confidence level for ...
[EN] Product design methodologies supporting creativity and innovation require tools and
methods that bridge divergent stages of analysis with concurrent stages of synthesis during
conceptual design. The simplified model ...
Kemp, Ian; van Millingen, Alex; Khaled, Houda; Iler, Lewis(Editorial Universitat Politècnica de València, 2018-09-07)
[EN] Simultaneous wetting and drying occur in processes such as fluid bed (top spray) granulation, Wurster coating and tablet film coating. This gives control challenges, as the spraying and evaporation processes must be ...
Scutellà, Bernadette; Trelea, Ioan Cristian; Bourlés, Erwan; Fonseca, Fernanda; Passot, Stephanie(Editorial Universitat Politècnica de València, 2018-09-07)
[EN] Freeze-drying is a dehydration method suitable for the stabilization of heat-labile pharmaceutical products, such as vaccines. Due to the vial-to-vial variability of heat and mass transfer during the process, the value ...