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Listar por palabra clave "Drug safety"

Mostrando ítems 1-4 de 4

Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Sanchez-De la Nava, Ana María; Arenal, Angel; Fernández-Avilés, Francisco; Atienza, Felipe (Frontiers Media SA, 2021-12-27)

[EN] Background: Antiarrhythmic drugs are the first-line treatment for atrial fibrillation (AF), but their effect is highly dependent on the characteristics of the patient. Moreover, anatomical variability, and specifically ...
Estudio y mejora de las estrategias para la credibilidad de modelos matemáticos biomédicos: Validación del efecto de fármacos en ensayos de seguridad farmacológica cardíaca

Ortigosa Calatayud, Carla (Universitat Politècnica de València, 2024-10-01)

[ES] La arritmia conocida como Torsade de Pointes (TdP) es una taquicardia ventricular potencialmente mortal que puede ser inducida por fármacos. Este hecho ha conllevado la retirada de ciertos medicamentos del mercado, ...
In silico assessment of drug safety in human heart applied to late sodium current blockers

Trénor Gomis, Beatriz Ana; Gomis-Tena Dolz, Julio; Cardona Urrego, Karen Eliana; Romero Pérez, Lucia; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R.; Saiz Rodríguez, Francisco Javier (Landes Bioscience, 2013-07-01)

Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...
When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

Gomis-Tena Dolz, Julio; Brown, Brandon M.; Cano, Jordi; Trenor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E.; Romero Pérez, Lucia (American Chemical Society, 2020-03-23)

[EN] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-a-go-go-related gene (hERG) channels, which is currently quantified by the ...

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Listar por palabra clave "Drug safety"

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