Sanchez-De la Nava, Ana María; Arenal, Angel; Fernández-Avilés, Francisco; Atienza, Felipe(Frontiers Media SA, 2021-12-27)
[EN] Background: Antiarrhythmic drugs are the first-line treatment for atrial fibrillation (AF), but their effect is highly dependent on the characteristics of the patient. Moreover, anatomical variability, and specifically ...
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development
of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...
Gomis-Tena Dolz, Julio; Brown, Brandon M.; Cano, Jordi; Trenor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E.; Romero Pérez, Lucia(American Chemical Society, 2020-03-23)
[EN] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-a-go-go-related gene (hERG) channels, which is currently quantified by the ...