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Listar por palabra clave "Experimental evolution"

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2b or not 2b: experimental evolution of functional exogenous sequences in a plant RNA virus

Willemsen, Anouk; Zwart, Mark Peter; Ambros Palaguerri, Silvia; Carrasco Jiménez, José Luis; Elena Fito, Santiago Fco (Oxford University Press, 2017)

[EN] Horizontal gene transfer (HGT) is pervasive in viruses and thought to be a key mechanism in their evolution. On the other hand, strong selective constraints against increasing genome size are an impediment for HGT, ...
Caracterización y mejora genética de la termotolerancia de levaduras del género Saccharomyces procedentes de diversos nichos ecológicos

Cerda García-Caro, Roberto de la (Universitat Politècnica de València, 2018-03-02)

[ES] Las levaduras son unos de los microrganismos más versátiles, ampliamente utilizados en diversos procesos biotecnológicos. Esto es debido a sus características metabólicas, como la producción de etanol y la tolerancia ...
Complex dynamics of defective interfering baculoviruses during serial passage in insect cells

Zwart, Mark Peter; Pijlman, G.P.; Sardanyes Cayuela, Jose; Duarte, J; Januario, C; Elena Fito, Santiago Fco (Springer Verlag (Germany), 2013-03)

Defective interfering (DI) viruses are thought to cause oscillations in virus levels, known as the 'Von Magnus effect'. Interference by DI viruses has been proposed to underlie these dynamics, although experimental tests ...
Determinación del espectro mutacional de Saccharomyces cerevisiae Y06240 tras diversificación genética mediante evolución experimental: efecto del método de extracción de DNA genómico y método de creación de librerías de DNAseq

Bono Soler, Pablo Luis (Universitat Politècnica de València, 2021-07-30)

[ES] La levadura Saccharomyces cerevisiae es uno de los organismos modelos que más se usan en Biotecnología y Biomedicina. De hecho, fue el primer eucariota en ser completamente secuenciado. Gracias al avance en secuenciación ...
Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations

Cervera-Benet, Héctor; Lalic, Jasna; Elena Fito, Santiago Fco (Royal Society, The, 2016-07-17)

[EN] Predicting viral evolution has proven to be a particularly difficult task, mainly owing to our incomplete knowledge of some of the fundamental principles that drive it. Recently, valuable information has been provided ...
Essentiality Is a Strong Determinant of Protein Rates of Evolution during Mutation Accumulation Experiments in Escherichia coli

Alvarez-Ponce, David; Sabater-Munoz, Beatriz; Toft, Chirstina; Ruíz-González, Mario Javier; Fares Riaño, Mario Ali (Oxford University Press (OUP), 2016-09)

[EN] The Neutral Theory of Molecular Evolution is considered the most powerful theory to understand the evolutionary behavior of proteins. One of the main predictions of this theory is that essential proteins should evolve ...
Evolutionary transitions during RNA virus experimental evolution

Elena Fito, Santiago Fco (Royal Society, The, 2016-08-19)

[EN] In their search to understand the evolution of biological complexity, John Maynard Smith and Eors Szathmary put forward the notion of major evolutionary transitions as those in which elementary units get together to ...
Experimental evolution of an emerging plant virus in host genotypes that differ in their susceptibility to infection

Hillung, Julia; Cuevas Torrijos, Jose Manuel; Valverde, Sergi; Elena Fito, Santiago Fco (Wiley, 2014-09)

[EN] This study evaluates the extent to which genetic differences among host individuals from the same species condition the evolution of a plant RNA virus. We performed a threefold replicated evolution experiment in which ...
Genetic variation in fitness within a clonal population of a plant RNA virus

Cervera-Benet, Héctor; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2016-01)

[EN] A long-standing observation in evolutionary virology is that RNA virus populations are highly polymorphic, composed by a mixture of genotypes whose abundances in the population depend on complex interaction between ...
High virulence does not necessarily impede viral adaptation to a new host: a case study using a plant RNA virus

Willemsen, Anouk; Zwart, Mark Peter; Elena Fito, Santiago Fco. (Springer (Biomed Central Ltd.), 2017)

[EN] Background: Theory suggests that high virulence could hinder between-host transmission of microparasites, and that virulence therefore will evolve to lower levels. Alternatively, highly virulent microparasites could ...
Local adaptation of plant viruses: lessons from experimental evolution

Elena Fito, Santiago Fco. (Blackwell Publishing, 2017)

[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and severity of ...
Multihost experimental evolution of a plant RNA virus reveals local adaptation and host specific mutations

Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2012-05)

[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and the severity ...
Plant virus evolution under strong drought conditions results in a transition from parasitism to mutualism

González, Rubén; Butkovic, Anamarija; Escaray, Francisco J.; Martínez-Latorre, Javier; Melero, Izan; Pérez-Parets, Enric; Gómez-Cadenas, Aurelio; Carrasco, Pedro; Elena, Santiago F. (Proceedings of the National Academy of Sciences, 2021-02-09)

[EN] Environmental conditions are an important factor driving pathogens' evolution. Here, we explore the effects of drought stress in plant virus evolution. We evolved turnip mosaic potyvirus in well-watered and drought ...
Predicting the Stability of Homologous Gene Duplications in a Plant RNA Virus

Willemsen, Anouk; Zwart, Mark Peter; Higueras, Pablo; Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2016-09)

One of the striking features of many eukaryotes is the apparent amount of redundancy in coding and non-coding elements of their genomes. Despite the possible evolutionary advantages, there are fewer examples of redundant ...
Role of host genetic diversity for susceptibility-to-infection in the evolution of virulence of a plant virus

González, Rubén; Butkovic, Anamarija; ELENA FITO, SANTIAGO FCO (Oxford University Press, 2019-07)

[EN] Predicting viral emergence is difficult due to the stochastic nature of the underlying processes and the many factors that govern pathogen evolution. Environmental factors affecting the host, the pathogen and the ...
Shrinkage of genome size in a plant RNA virus upon transfer of an essential gene into the host genome

Tromas, Nicolas; Zwart, Mark Peter; Forment Millet, José Javier; Elena Fito, Santiago Fco (Oxford University Press, 2014)

[EN] Nonretroviral integrated RNA viruses (NIRVs) are genes of nonretroviral RNA viruses found in the genomes of many eukaryotic organisms. NIRVs are thought to sometimes confer virus resistance, meaning that they could ...
Study of Spatiotemporal Responses of Bacterial Cells

Montagud Martínez, Roser (Universitat Politècnica de València, 2023-04-28)

[ES] La biotecnología moderna se basa en la aplicación de una mezcla de herramientas experimentales y computacionales para llevar a cabo de forma dirigida la ingeniería genética. El objetivo es obtener células (re)programadas ...
Temporal Dynamics of Intrahost Molecular Evolution for a Plant RNA Virus

Cuevas, Jose M.; Willemsen, A; Hillung, Julia; Zwart, Mark Peter; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2015-05)

[EN] Populations of plant RNA viruses are highly polymorphic in infected plants, which may allow rapid within-host evolution. To understand tobacco etch potyvirus (TEV) evolution, longitudinal samples from experimentally ...
The Molecular Chaperone DnaK Is a Source of Mutational Robustness

Aguilar-Rodríguez, Jose; Sabater-Munoz, Beatriz; Montagud-Martinez, Roser; Berlanga, Victor; Alvarez-Ponce, David; Wagner, Andreas; Fares Riaño, Mario Ali (Oxford University Press (OUP), 2016-09)

[EN] Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. Thanks to these abilities, some chaperones, such as the Hsp90 protein or the ...
The transcriptomics of an experimentally evolved plant-virus interaction

Hillung, Julia; García-García, Francisco; DOPAZO, JOAQUÍN; Cuevas Torrijos, Jose Manuel; Elena Fito, Santiago Fco (Nature Publishing Group, 2016-04-26)

[EN] Models of plant-virus interaction assume that the ability of a virus to infect a host genotype depends on the matching between virulence and resistance genes. Recently, we evolved tobacco etch potyvirus (TEV) lineages ...