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Listar por palabra clave "Fibronectin"

Mostrando ítems 1-20 de 23

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3D Culture o Multiple Myeloma Cell Line Using Microgel Environments

Marin Paya, Juan Carlos (Universitat Politècnica de València, 2021-06-03)

[ES] El mieloma múltiple es una neoplasia hematológica caracterizada por una expansión descontrolada de células plasmáticas monoclonales (mPCs) en medula ósea que producen, en la mayoría de los casos, un componente monoclonal ...
BIOLOGICAL ACTIVITY OF FIBRONECTIN AT THE CELL-MATERIAL INTERFACE

González García, Cristina (Universitat Politècnica de València, 2012-11-05)

Esta tesis aborda la actividad biológica de la fibronectina (FN) como proteína de interfase en la interacción célula-material. La tesis investiga la respuesta de la proteína, en términos de cantidad adsorbida y conformación, ...
Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway

Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; Sánchez-Pérez, Laura; Salmerón Sánchez, Manuel (Springer Nature, 2020-11-27)

[EN] The intrinsic properties of mesenchymal stem cells (MSCs) make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ...
Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry

MNATSAKANYAN, HAYK; Rico Tortosa, Patricia María; Grigoriou, Eleni; Maturana Candelas, Aarón; Rodrigo Navarro, Aleixandre; Salmerón Sánchez, Manuel; Sabater i Serra, Roser (American Chemical Society, 2015-08-19)

Fibronectin fibrillogenesis is the physiological process by which cells elaborate a fibrous FN matrix. Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) ...
Dynamic Mechanical Control of Alginate-Fibronectin Hydrogels with Dual Crosslinking: Covalent and Ionic

Trujillo-Muñoz, Sara; Seow, Melanie; Lueckgen, Aline; Salmerón Sánchez, Manuel; Cipitria, Amaia (MDPI AG, 2021-02)

[EN] Alginate is a polysaccharide used extensively in biomedical applications due to its biocompatibility and suitability for hydrogel fabrication using mild reaction chemistries. Though alginate has commonly been crosslinked ...
Effect of topological cues on material-driven fibronectinfibrillogenesis and cell differentiation

Ballester Beltrán, José; Cantini, Marco; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Moratal Pérez, David; García, Andrés J.; Salmerón Sánchez, Manuel (Springer Verlag (Germany), 2012-01)

[EN] Fibronectin (FN) assembles into fibrillar networks by cells through an integrin-dependent mechanism. We have recently shown that simple FN adsorption onto poly(ethyl acrylate) surfaces (PEA), but not control polymer ...
Engineered 3D hydrogels with full-length fibronectin that sequester and present growth factors

Trujillo-Muñoz, Sara; González-García, Cristina; Rico Tortosa, Patricia María; Reid, Andrew; Windmill, James; Dalby, Matthew J.; Salmerón Sánchez, Manuel (Elsevier, 2020-09)

[EN] Extracellular matrix (ECM)-derived matrices such as Matrigel are used to culture numerous cell types in vitro as they recapitulate ECM properties that support cell growth, organisation, migration and differentiation. ...
Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization

Moulisova, Vladimira; González García, Cristina; Cantini, Marco; Rodrigo Navarro, Aleixandre; Weaver, Jessica; Costell, Mercedes; Sabater i Serra, Roser; Dalby, Matthew J.; García, Andrés J.; Salmerón Sánchez, Manuel (Elsevier, 2017)

[EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...
Estudio del efecto del boro y su transportador en células de cáncer de colon

Talamanca Buitrago, Blanca (Universitat Politècnica de València, 2022-09-07)

[ES] El cáncer de colon es la neoplasia maligna más frecuente que se puede presentar en el tubo digestivo y, a pesar de la incesante investigación, una de las patologías con mayor prevalencia en la población mundial. El ...
Fibronectin distribution on demixed nanoscale topographies

Perez Garnes, Manuel; González García, Cristina; Moratal Pérez, David; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel (Wichtig Editore, 2011-02-04)

[EN] Purpose: It is known that surface nanotopography influences cell adhesion and differentiation. Our aim is to analyze the effect of nanoscale topography on fibronectin adsorption and, afterwards, on cell adhesion in ...
Functional living biointerfaces to direct cell-material interaction

Rodrigo Navarro, Aleixandre (Universitat Politècnica de València, 2015-06-10)

[EN] This thesis deals with the development of a living biointerface between synthetic substrates and living cells to engineer cell-material interactions for tissue engineering purposes. This living biointerface is made ...
Functional Living Biointerphases

Saadeddin Saadeddin, Anas; Rodrigo Navarro, Aleixandre; Monedero, Vicente; Rico Tortosa, Patricia María; Moratal Pérez, David; González-Martín, María Luisa; Navarro, David; García, Andrés J.; Salmerón Sánchez, Manuel (Wiley, 2013-09)

Lactococcus lactis is modified to express a fibronectin fragment (FNIII₇₋₁₀) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal ...
Functionalization of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks

Sprott, Mark Robert; Gallego-Ferrer, Gloria; Dalby, Matthew J.; Salmerón Sánchez, Manuel; Cantini, Marco (Wiley-VCH, 2019-02-07)

[EN] Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this polymer make it a versatile and useful resource for regenerative medicine. However, it is not inherently ...
Material-driven fibronectin fibrillogenesis to engineer cell function

Llopis Hernández, Virginia (Universitat Politècnica de València, 2017-11-03)

This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It ...
Protein-Functionalized Microgel for Multiple Myeloma Cells' 3D Culture

Marin-Paya, Juan Carlos; Clara-Trujillo, Sandra; Cordón, Lourdes; Gallego-Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís (MDPI AG, 2022-11)

[EN] Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the ...
Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture

Marín Pallá, Juan Carlos; Clara Trujillo, Sandra; Cordón, Lourdes; Gallego Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís (MDPIUniversitat Politècnica de València, 2022-11-21)

Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is tightly related to the bone ...
Role of chemical crosslinking in material-driven assembly offibronectin (nano)networks: 2D surfaces and 3D scaffolds

Sabater i Serra, Roser; León-Boigues, Laia; Sánchez Laosa, Antonio; Gómez Estrada, Luis; Gómez Ribelles, José Luís; Salmerón Sánchez, Manuel; Gallego-Ferrer, Gloria (Elsevier, 2016-12-01)

Poly(ethyl acrylate) (PEA) induces the formation of biomimetic fibronectin (FN) (nano)networks uponsimple adsorption from solutions, a process referred to as material-driven FN fibrillogenesis. The ability ofPEA to organize ...
Role of fibronectin in topographical guidance of neurite extension onelectrospun fibers

Mukhatyar, Vivek J.; Salmerón Sánchez, Manuel; Rudra, Soumon; Mukhopadaya, Shoumit; Barker, Thomas H.; Garcia, Andres J.; Bellamkonda, Ravi V. (Elsevier, 2011)

Bridging of long peripheral nerve gaps remains a significant clinical challenge. Electrospun nanofibers have been used to direct and enhance neurite extension in vitro and in vivo. While it is well established that oriented ...
Role of material-driven fibronectin fibrillogenesis in cell differentiation

Salmerón Sánchez, Manuel; Rico Tortosa, Patricia María; Moratal Pérez, David; Lee, Ted T.; Schwarzbauer, Jean E.; Garcia, Andres J. (Elsevier, 2011)

Fibronectin (FN) is a ubiquitous extracellular matrix protein (ECM) protein that is organized into fibrillar networks by cells through an integrin-mediated process that involves contractile forces. This assembly allows for ...
Role of surface chemistry in protein remodeling at the cell-material interface

Llopis Hernández, Virginia; Rico Tortosa, Patricia María; Ballester Beltrán, José; Moratal Pérez, David; Salmerón Sánchez, Manuel (Public Library of Science, 2011)

Background: The cell-material interaction is a complex bi-directional and dynamic process that mimics to a certain extent the natural interactions of cells with the extracellular matrix. Cells tend to adhere and rearrange ...