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Listar por palabra clave "Glioblastoma"

Mostrando ítems 1-20 de 23

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A gated material as immunosensor for in-tissue detection of IDH1-R132H mutation in gliomas

Pla, Luis; Sancenón Galarza, Félix; Martínez-Bisbal, M.Carmen; Prat-Acín, Ricardo; Galeano-Senabre, Inmaculada; Botello-Marabotto, Marina Dolores; Palanca-Suela, Sarai; Aznar, Elena; Santiago Felipe, Sara; Martínez-Máñez, Ramón (Elsevier, 2021-10-15)

[EN] A nanodevice consisted on nanoporous anodic alumina (NAA) supports functionalized with specific and selective antibody-based gatekeepers for the detection of IDH1-R132H mutant enzyme is here reported. Molecular profile ...
Decreased tissue stiffness in glioblastoma by MR elastography is associated with increased cerebral blood flow

Svensson, Siri Fløgstad; Fuster García, Elíes; Latysheva, Anna; Fraser-Green, Jorunn; Nordhoy, Wibeke; Darwish, Omar Isam; Hovden, Ivar Thokle; Holm, Sverre; Vik-Mo, Einar O.; Sinkus, Ralph; Emblem, Kyrre Eeg (Elsevier, 2022-02)

[EN] Purpose: Understanding how mechanical properties relate to functional changes in glioblastomas may help explain different treatment response between patients. The aim of this study was to map differences in biome-chanical ...
Desarrollo de un estudio clínico observacional multicéntrico retrospectivo para validar la tecnología de análisis de imagen médica OncoHabitats

Bellvis Bataller, Fuensanta (Universitat Politècnica de València, 2018-10-16)

[ES] El Glioblastoma es uno de los tumores primarios del sistema nervioso central más frecuente en adultos con una supervivencia media de 15 meses. Desde la publicación del tratamiento Stupp estándar en el año 2005, ninguna ...
Differential effect of vascularity between long- and short-term survivors with IDH1/2 wild-type glioblastoma

Álvarez-Torres, María del Mar; Fuster García, Elíes; Reynes, Gaspar; Juan-Albarracín, Javier; Chelebian-Kocharyan, Eduard Artur; Oleaga, Laura; Pineda, Jose; Auger, Cristina; Rovira, Alex; Emblem, Kyrre E.; Filice, Silvano; Molla-Olmos, Enrique; Garcia-Gomez, Juan M (John Wiley & Sons, 2021-04)

[EN] Introduction: IDH1/2 wt glioblastoma (GB) represents the most lethal tumour of the central nervous system. Tumour vascularity is associated with overall survival (OS), and the clinical relevance of vascular markers, ...
Diseño de un clasificador radiogenómico de glioblastoma basado en redes convolucionales para la identificación de subtipos moleculares a partir de imágenes de resonancia magnética

Chelebian Kocharyan, Eduard Artur (Universitat Politècnica de València, 2019-07-02)

[ES] El Glioblastoma Multiforme (GBM) constituye el 60% de todos los tumores cerebrales en adultos. Es la más frecuente de las neoplasias que afectan a las células gliales y también la más maligna, con un pésimo pronóstico. ...
Diseño y desarrollo de un algoritmo de segmentación automática de vasos sanguíneos cerebrales sanos en pacientes con glioblastoma basándose en imágenes de resonancia magnética multimodales

Diez Alonso, Pablo (Universitat Politècnica de València, 2019-09-30)

[ES] El glioblastoma multiforme (GBM) afecta anualmente a 1 de cada 33.000 personas, aproximadamente, representando un 47 % de todos los casos de tumores cerebrales malignos. Este tipo de tumores se caracteriza por su ...
Drug Dellivery to the Brain Using Polymer Therapeutics as an Intranasal Platform for Pediatric Glioblastoma Treatment

Melnyk, Tetiana (Universitat Politècnica de València, 2025-03-07)

[ES] Los tumores malignos del cerebro y del sistema nervioso central representan el 21% de los tumores en niños y son la segunda causa principal de muerte por cáncer pediátrico después de la leucemia. Los gliomas de alto ...
Estudio de la predicción de supervivencia en glioblastoma mediante redes neuronales convolucionales usando imágenes de resonancia magnética multimodal

Chelebian Kocharyan, Eduard Artur (Universitat Politècnica de València, 2021-01-20)

[ES] Aproximadamente el 75% de todos los tumores primarios malignos de cerebro en adultos son gliomas. El glioblastoma, el más letal de entre ellos, representa más de la mitad de los gliomas. Con una supervivencia mediana ...
Estudio de regresión de biomarcadores basados en firmas tisulares hemodinámicas y proteínas circulantes en pacientes con glioblastoma

Francés Oliver, Lorena (Universitat Politècnica de València, 2016-07-12)

[ES] En este Trabajo de Fin de Grado se ha realizado un estudio de regresión entre biomarcadores de imagen de RM y proteínas circulantes relacionados con glioblastoma en una cohorte de 13 pacientes diagnosticados en el ...
Glioblastoma versus solitary brain metastasis: MRI differentiation using the edema perfusion gradient

Aparici-Robles, Fernando; Davidhi, Andjoli; Carot Sierra, José Miguel; Perez-Girbes, Alexandre; Carreres-Polo, Joan; Mazón-Momparler, Miguel; Juan-Albarracín, Javier; Fuster García, Elíes; Garcia-Gomez, Juan M (Blackwell Publishing, 2022-01)

[EN] Background and Purpose: Differentiation between glioblastoma multiforme (GBM) and solitary brain metastasis (SBM) remains a challenge in neuroradiology with up to 40% of the cases to be incorrectly classified using ...
High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 1: Perfusion and Diffusion Techniques

Henriksen, Otto M.; Álvarez-Torres, María del Mar; Figueiredo, Patricia; Hangel, Gilbert; Keil, Vera C.; Nechifor, Ruben E.; Riemer, Frank; Schmainda, Kathleen M.; Warnert, Esther A. H.; Wiegers, Evita C.; Booth, Thomas C. (Frontiers Media SA, 2022-03-03)

[EN] Objective: Summarize evidence for use of advanced MRI techniques as monitoring biomarkers in the clinic, and highlight the latest bench-to-bedside developments. Methods: Experts in advanced MRI techniques applied to ...
High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 2: Spectroscopy, Chemical Exchange Saturation, Multiparametric Imaging, and Radiomics

Booth, Thomas C.; Wiegers, Evita C.; Warnert, Esther A. H.; Schmainda, Kathleen M.; Riemer, Frank; Nechifor, Ruben E.; Keil, Vera C.; Hangel, Gilbert; Figueiredo, Patrícia; Álvarez-Torres, María del Mar; Henriksen, Otto M. (Frontiers Media SA, 2022-02-28)

[EN] ObjectiveTo summarize evidence for use of advanced MRI techniques as monitoring biomarkers in the clinic, and to highlight the latest bench-to-bedside developments. MethodsThe current evidence regarding the potential ...
Improving the estimation of prognosis for glioblastoma patients by MR based hemodynamic tissue signatures

Fuster García, Elíes; Juan -Albarracín, Javier; García-Ferrando, Germán Adrián; Martí-Bonmatí, Luis; Aparici-Robles , F; Garcia-Gomez, Juan M (John Wiley & Sons, 2018)

[EN] Advanced MRI and molecular markers have been raised as crucial to improve prognostic models for patients having glioblastoma (GBM) lesions. In particular, different MR perfusion based markers describing vascular ...
Interpreting deep learning models for glioma survival classification using visualization and textual explanations.

Osadebey, Michael; Liu, Qinghui; Fuster García, Elíes; Emblem, Kyrre E. (BioMed Central, 2023-10-18)

[EN] Background Saliency-based algorithms are able to explain the relationship between input image pixels and deeplearning model predictions. However, it may be difcult to assess the clinical value of the most important ...
Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain

Sánchez-Dengra, Barbara; Alfonso, María; Gonzalez-Alvarez, Isabel; Bermejo, Marival; Gonzalez -Alvarez, Marta; Martínez-Máñez, Ramón (Future Medicine, 2023-10)

[EN] Background: Glioblastoma is the most common and lethal brain cancer. New treatments are needed. However, the presence of the blood-brain barrier is limiting the development of new treatments directed toward the brain, ...
Lack of Benefit of Extending Temozolomide Treatment in Patients with High Vascular Glioblastoma with Methylated MGMT

Álvarez-Torres, María del Mar; Fuster García, Elíes; Balaña, Carmen; Puig, Josep; Garcia-Gomez, Juan M (MDPI AG, 2021-11)

[EN] Despite the complete treatment with surgery, chemotherapy and radiotherapy, patients with glioblastoma have a devasting prognosis. Although the role of extending temozolomide treatment has been explored, the results ...
Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification

Álvarez-Torres, María del Mar; Fuster García, Elíes; Juan-Albarracín, Javier; Reynes, Gaspar; Aparici-Robles, Fernando; Ferrer Lozano, Jaime; Garcia-Gomez, Juan M (Springer (Biomed Central Ltd.), 2022-01-06)

[EN] Background The microvessels area (MVA), derived from microvascular proliferation, is a biomarker useful for high-grade glioma classification. Nevertheless, its measurement is costly, labor-intense, and invasive. Finding ...
Magnetic resonance spectroscopy and imaging on fresh human brain tumor biopsies at microscopic resolution

Martínez-Bisbal, M.Carmen; Martínez-Granados, Beatriz; Rovira, Vicente; Celda, Bernardo; Esteve, Vicent (Springer Verlag (Germany), 2015-09)

[EN] The metabolic compn. and concn. knowledge provided by magnetic resonance spectroscopy (MRS) liq. and high-resoln. magic angle spinning spectroscopy (HR-MAS) has a relevant impact in clin. practice during magnetic ...
MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas

Fuster García, Elíes; Lorente Estellés, David; Álvarez-Torres, María del Mar; Juan-Albarracín, Javier; Chelebian-Kocharyan, Eduard Artur; Rovira, Alex; Auger Acosta, Cristina; Pineda, Jose; Oleaga, Laura; Mollá-Olmos, Enrique; Filice, Silvano; Due-Tonnessen, Paulina; Meling, Torstein R.; Emblem, Kyrre E.; Garcia-Gomez, Juan M (Springer-Verlag, 2021-03)

[EN] Objectives To assess the combined role of tumor vascularity, estimated from perfusion MRI, andMGMTmethylation status on overall survival (OS) in patients with glioblastoma. Methods A multicentric international dataset ...
Radiomics for diagnosis and assessing brain diseases: an approach based on texture analysis on magnetic resonance imaging

Ortiz Ramón, Rafael (Universitat Politècnica de València, 2019-04-08)

[ES] En los últimos años, los investigadores han intentado explotar la información de las imágenes médicas a través de la evaluación de parámetros cuantitativos para ayudar a los clínicos con el diagnóstico de enfermedades. ...