Vanacloig Pedros, Mª ELENA; Bets Plasencia, Carolina; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(American Society for Biochemistry and Molecular Biology, 2015-04-17)
[EN] Stress triggers complex transcriptional responses, which include both gene activation and repression. We used time-resolved reporter assays in living yeast cells to gain insights into the coordination of positive and ...
Manzanares Estreder, Sara(Universitat Politècnica de València, 2017-03-27)
In the present work we study the metabolic adaptation in response to stress in the yeast model, and more specifically we investigate the regulation of peroxisomal activity and the metabolism of sphingolipids.
Peroxisomes ...
Rienzo, Alessandro(Universitat Politècnica de València, 2016-04-05)
[EN] Cells respond to environmental stimuli by fine tuned regulation of gene expression. In this thesis we investigate the dose dependent modulation of the genetic response upon nutrient and stress signals in yeast. A ...
Manzanares-Estreder, Sara; Espí Bardisa, Joan; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans(Blackwell Publishing, 2016)
[EN] Peroxisomes are dynamic organelles and the sole location for fatty acid ß-oxidation in yeast cells. Here, we report that peroxisomal function is crucial for the adaptation to salt stress, especially upon sugar limitation. ...
Vendrell, Alexandre; Martínez Pastor, María Mar; González-Novo, Alberto; Pascual-Ahuir Giner, María Desamparados; Sinclair, David A.; Proft, Markus; Posas, Francesc(EMBO Press, 2011)
[EN] Exposure of yeast to high osmolarity induces a transient activation
of the Hog1 stress-activated protein kinase (SAPK), which
is required for cell survival under these conditions. However,
sustained activation of ...