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Listar por palabra clave "Hyaluronic acid"

Mostrando ítems 1-20 de 35

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3D Culture o Multiple Myeloma Cell Line Using Microgel Environments

Marin Paya, Juan Carlos (Universitat Politècnica de València, 2021-06-03)

[ES] El mieloma múltiple es una neoplasia hematológica caracterizada por una expansión descontrolada de células plasmáticas monoclonales (mPCs) en medula ósea que producen, en la mayoría de los casos, un componente monoclonal ...
A Hyaluronic Acid Demilune Scaffold and Polypyrrole-Coated Fibers Carrying Embedded Human Neural Precursor Cells and Curcumin for Surface Capping of Spinal Cord Injuries

Elkhenany, Hoda; Bonilla, Pablo; Giraldo-Reboloso, Esther; Alastrue Agudo, Ana; Edel, Michael J.; Vicent, María Jesus; Gisbert-Roca, Fernando; Martínez-Ramos, Cristina; Rodriguez Doblado, Laura; Monleón Pradas, Manuel; Moreno Manzano, Victoria (MDPI AG, 2021-12)

[EN] Tissue engineering, including cell transplantation and the application of biomaterials and bioactive molecules, represents a promising approach for regeneration following spinal cord injury (SCI). We designed a ...
A New Hyaluronic Emulgel of Hesperetin for Topical Application-An In Vitro Evaluation

Talens-Visconti, Raquel; Belarbi, Yousra; Díez-Sales, Octavio; de Julián-Ortiz, Jesús Vicente; Vila Busó, M.A. Ofelia; Nácher, Amparo (MDPI AG, 2024-04)

[EN] The present study aimed to formulate and characterize a hesperetin formulation to achieve adequate deposition and retention of hesperetin in the epidermis as a target for some cosmetic/dermatological actions. To derive ...
Biohybrids for spinal cord injury repair

Martínez-Ramos, Cristina; Rodriguez Doblado, Laura; López Mocholi, Eric; Alastrue-Agudo, Ana; Sánchez Petidier, Marina; Giraldo-Reboloso, Esther; Monleón Pradas, Manuel; Moreno-Manzano, Victoria (John Wiley & Sons, 2019-03)

[EN] Spinal cord injuries (SCIs) result in the loss of sensory and motor function with massive cell death and axon degeneration. We have previously shown that transplantation of spinal cord-derived ependymal progenitor ...
Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke.

Sanchez-Rojas, Leyre; Gómez-Pinedo, Ulises; Benito-Martin, María Soledad; León-Espinosa, Gonzalo; Rascón-Ramirez, Fernando; Lendinez, Cristina; Martínez-Ramos, Cristina; Matías-Guiu, Jorge; Monleón Pradas, Manuel; Barcia, Juan A. (John Wiley & Sons, 2019-07)

[EN] Endogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds ...
Biomimetic 3D environment based on microgels as a model for the generation of drug resistance in multiple myeloma

Marín-Payá, Juan Carlos; Díaz-Benito, Blanca; Amaro Martins, Luis; Clara Trujillo, Sandra; Cordón, Lourdes; Lanceros-Méndez, Senentxu; Gallego-Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís (MDPI AG, 2021-12)

[EN] The development of three-dimensional environments to mimic the in vivo cellular response is a problem in the building of disease models. This study aimed to synthesize and validate three-dimensional support for culturing ...
Biomimetic 3D Environment Based on Microgels as a Model for the Generation of Drug Resistance in Multiple Myeloma

Marin Paya, Juan Carlos; Díaz Benito, Blanca; Amaro Martins, Luis; Clara Trujillo, Sandra; Cordón, Lourdes; Lanceros-Mendez, Senentxu; Gallego Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís (Universitat Politècnica de València, 2021-12-14)

The development of three-dimensional environments to mimic the in vivo cellular response is a problem in the building of disease models. This study aimed to synthesize and validate three-dimensional support for culturing ...
Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo

Lebourg, Myriam Madeleine; Martínez Díaz, S.; Garcia Giralt, Natalia; Torres Claramunt, R.; Gómez-Tejedor, José Antonio; Gómez Ribelles, José Luís; Vila Canet, G; Monllau, J.C. (SAGE Publications (UK and US), 2014-05)

Polycaprolactone scaffolds modified with cross-linked hyaluronic acid were prepared in order to establish whether a more hydrophilic and biomimetic microenvironment benefits the progenitor cells arriving from bone marrow ...
Conduits based on the combination of hyaluronic acid and silk fibroin: Characterization, in vitro studies and in vivo biocompatibility

Gisbert-Roca, Fernando; Lozano Picazo, Paloma; Pérez-Rigueiro, José; Guinea Tortuero, Gustavo Victor; Monleón Pradas, Manuel; Martínez-Ramos, Cristina (Elsevier, 2020-04-01)

[EN] We address the production of structures intended as conduits made from natural biopolymers, capable of promoting the regeneration of axonal tracts. We combine hyaluronic acid (HA) and silk fibroin (SF) with the aim ...
Desarrollo de hidrogeles biomiméticos inyectables para cultivo celular hepático

Rodríguez Fernández, Julio (Universitat Politècnica de València, 2021-02-02)

[ES] Los métodos de cultivo de células que simulan el tejido, los cuales promueven la función específica del hígado durante un período prolongado, son herramientas prometedoras para la ingeniería de tejidos hepática y los ...
Desarrollo de un hidrogel combinado con células como sistema de trasplante para lesión medular

Villa Sánchez, Camila Alejandra (Universitat Politècnica de València, 2021-09-17)

[EN] Central and peripheral nervous system injuries such as nerve injuries and spinal cord injury are diseases with a high incidence today due to trauma situations, the consequences of these traumas are high in the quality ...
Desarrollo de un sistema de liberación prolongada de factor neural del crecimiento a partir de micropartículas de gelatina introducidas en dos scaffolds de ácido hialurónico y poli( etil acrilato

Rodríguez Ruiz, Alejandro (Universitat Politècnica de València, 2014-09-26)

[EN] Nowadays there are lots of diseases with a neurologic origin where the pathogenic common marker is the loss of specific groups of neurons, for example; Parkinson disease with the degener ...
Desarrollo de un viscosuplemento gelificable in situ basado en ácido hialurónico entrecruzado para liberación controlada de moléculas condroprotectoras

Torregrosa Aragoneses, Irene (Universitat Politècnica de València, 2022-09-02)

[ES] La osteoartritis (OA) es una enfermedad degenerativa, crónica y compleja que provoca la alteración estructural y funcional de las articulaciones y que afecta actualmente a 300 millones de personas. El objetivo ...
Development and evaluation of hyaluronan nanocomposite conduits for neural tissue regeneration

Mullor Ruiz, Ismael; Vilariño-Feltrer, Guillermo; Mnatsakanyan, Hayk; Vallés Lluch, Ana; Monleón Pradas, Manuel (Taylor & Francis, 2021-11-22)

[EN] Hyaluronan-based hydrogels are among the most promising neural tissue engineering materials because of their biocompatibility and the immunomodulation capabilities of their degradation byproducts. Despite these features, ...
Diseño de hidrogeles de ácido hialurónico injertados con moléculas condroprotectoras

Seguí Esquembre, Carmen (Universitat Politècnica de València, 2024-02-16)

[ES] La artrosis es una enfermedad degenerativa de las articulaciones que afecta a un gran número de personas. Según las estadísticas más recientes, se estima que la incidencia de la artrosis en España es del 10% de la ...
Diseño de nuevos biomateriales por combinación de fibroina y ácido hialurónico

Gisbert Roca, Fernando (Universitat Politècnica de València, 2018-01-09)

[ES] Las lesiones y enfermedades que afectan al sistema nervioso, tanto central (SNC) como periférico (SNP), poseen incidencias y prevalencias muy elevadas, afectando a millones de personas en todo el mundo. Además, el ...
Diseño del bioproceso productivo de ácido hialurónico

Arévalo Aguado, Jordi (Universitat Politècnica de València, 2019-10-22)

[ES] El en presente TFG se describirá la producción de ácido hialurónico a escala industrial por medio de un bioproceso. Se debe prestar especial atención al tipo de bioproceso seleccionado: microorganismo, sustrato, ...
Effect of electrical stimulation on chondrogenic differentiation of mesenchymal stem cells cultured in hyaluronic acid - Gelatin injectable hydrogels

Vaca-González, Juan Jairo; Clara-Trujillo, Sandra; Guillot-Ferriols, María Teresa; Ródenas Rochina, Joaquín; Sanchis Sánchez, María Jesús; Gómez Ribelles, José Luís; Garzón-Alvarado, Diego Alexander; Gallego-Ferrer, Gloria (Elsevier, 2020-08)

[EN] Electrical stimulation (ES) has provided enhanced chondrogenesis of mesenchymal stem cells (MSCs) cultured in micro-mass without the addition of exogenous growth factors. In this study, we demonstrate for the first ...
Electrospun adherent-antiadherent bilayered membranes based on cross-linked hyaluronic acid for advanced tissue engineering applications

Arnal Pastor, María Pilar; Martínez Ramos, Cristina; Perez Garnes, Manuel; Monleón Pradas, Manuel; Vallés Lluch, Ana (Elsevier, 2013-10-01)

[EN] A procedure to obtain electrospun mats of hyaluronic acid (HA) stable in aqueous media in one single step has been developed. It consists in combining an HA solution with a divinyl sulfone one as cross-linker in a ...
Estudio de la viabilidad de células de mieloma múltiple cultivadas en entornos tridimensionales biomiméticos de médula ósea

Esteban Arias, Angela (Universitat Politècnica de València, 2019-09-03)

[ES] Actualmente la producción de modelos de médula ósea tridimensionales supone un reto en el campo de la ingeniería tisular ya que permitiría el avance hacia tratamientos personalizados en pacientes de mieloma múltiple ...