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Listar por palabra clave "Immunotherapy"

Mostrando ítems 1-16 de 16

Analysis of the Gut Microbiota: An Emerging Source of Biomarkers for Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

Zhang, Feiyu; Ferrero, Macarena; Dong, Ning; D Auria, Giuseppe; Reyes-Prieto, Mariana; Herreros-Pomares, Alejandro; Calabuig-Fariñas, Silvia; Durendez, Elena; Aparisi, Francisco; Blasco, Ana; García, Clara; Camps, Carlos; Jantus-Lewintre, Eloisa; Sirera Pérez, Rafael (MDPI AG, 2021-06)

[EN] Background: The human gut harbors around 10(13)-10(14) microorganisms, collectively referred to as gut microbiota. Recent studies have found that the gut microbiota may have an impact on the interaction between immune ...
Caracterización del repertorio de receptores de linfocitos T de sangre periférica en pacientes con carcinoma de pulmón no microcítico tratados con inmunoterapia

Panizza, Antolina (Universitat Politècnica de València, 2020-10-13)

[ES] El cáncer de pulmón representa la principal causa de muerte por cáncer en todo el mundo, con una supervivencia global a los 5 años del 19%. Actualmente, existe una nueva estrategia terapéutica basada en el sistema ...
Characterization of Circulating T Cell Receptor Repertoire Provides Information about Clinical Outcome after PD-1 Blockade in Advanced Non-Small Cell Lung Cancer Patients

Dong, Ning; Moreno-Manuel, Andrea; Calabuig-Fariñas, Silvia; Gallach, Sandra; Zhang, Feiyu; Blasco, Ana; Aparisi, Francisco; Meri-Abad, Marina; Guijarro, Ricardo; Sirera Pérez, Rafael; Camps, Carlos; Jantus-Lewintre, Eloisa (MDPI AG, 2021-06)

[EN] Despite the success of immunotherapies in lung cancer, development of new biomarkers for patient selection is urgently needed. This study aims to explore minimally invasive approaches to characterize circulating T ...
Characterization of Tumor Cells and Immune Microenvironment Interactions in Non Small Cell Lung Cancer. Translational implications

Torres Martínez, Susana (Universitat Politècnica de València, 2024-04-22)

[ES] En esta tesis, buscamos profundizar en el estudio del microambiente inmunitario del tumor (TME), lo que resultaría en una mejor caracterización del contexto inmunológico de los pacientes y la búsqueda de nuevos ...
e Comprehensive NGS panel for cancer-biomarkers assessment: validation of its analytical and clinical performance

García Parra, Nadia (Universitat Politècnica de València, 2021-07-30)

[ES] El cáncer es la primera causa de muerte en países desarrollados. Se trata de una compleja enfermedad genética causada por un gran abanico de alteraciones y las interacciones entre las mismas. El conocimiento de ...
HMGB1 Expression Levels Correlate with Response to Immunotherapy in Non-Small Cell Lung Cancer

Gonzalez-Cao, Maria; Cai, Xueting; Bracht, Jilian Wilhelmina Paulina; Han, Xuan; Yang, Yang; Pedraz-Valdunciel, Carlos; Morán, Teresa; García-Corbacho, Javier; Aguilar, Andrés; Bernabé, Reyes; De Marchi, Pedro; da Silva, Luciane Sussuchi; Ferro Leal, Leticia; Reis, Rui Manuel; Codony-Servat, Jordi; Jantus-Lewintre, Eloisa (2024-05-09)

[EN] Purpose: High-mobility group box 1 protein (HMGB1) is subject to exportin 1 (XPO1)-dependent nuclear export, and it is involved in functions implicated in resistance to immunotherapy. We investigated whether HMGB1 ...
Impact of SARS-CoV-2 Infection on Patients with Cancer: Retrospective and Transversal Studies in Spanish Population

Garde-Noguera, Javier; Fernández-Murga, M. Leonor; Giner-Bosch, Vicent; Domínguez-Márquez, Victoria; García Sánchez, José; Soler-Cataluña, Juan José; López Chuliá, Francisca; Honrubia, Beatriz; Piera, Nuria; Llombart-Cussac, Antonio (MDPI AG, 2020-12)

[EN] Background: Studies of patients with cancer affected by coronavirus disease 2019 (COVID-19) are needed to assess the impact of the disease in this sensitive population, and the influence of different cancer treatments ...
Inflammatory Tumor Microenvironment as target in the design of nanoconjugates for the treatment of advanced breast cancer

Soriano Teruel, Paula (Universitat Politècnica de València, 2023-03-13)

[ES] Esta tesis doctoral titulada "El microambiente tumoral inflamatorio como objetivo en el diseño de nanoconjugados para el tratamiento del cáncer de mama avanzado" se centra en la evaluación de un nuevo inhibidor del ...
KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination

Rosell, R; Jantus-Lewintre, Eloisa; Cao, Peng; Cai, Xueting; Xing, Baojuan; Ito, Masaoki; Gomez-Vazquez, Jose Luis; Marco-Jordán, Mireia; Calabuig-Farinas, Silvia; Cardona, Andrés F.; Codony-Servat, Jordi; Gonzalez, Jessica; València-Clua, Kevin; Aguilar, Andrés; Pedraz-Valdunciel, Carlos (BioMed Central, 2024-06-12)

[EN] Background KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS-G12C selective inhibitors, leading to short median progression-free survival, and ...
Lung Cancer and SARS-CoV-2 infection: Identifying important knowledge gaps for investigation

Rolfo, Christian; Meshulami, Noy; Russo, Alessandro; Krammer, Florian; Garcia-Sastre, Adolfo; Mack, Philip C.; Gomez, Jorge E.; Bhardwaj, Nina; Benyounes, Amin; Sirera Pérez, Rafael; Moore, Amy; Rohs, Nicholas; Henschke, Claudia I.; Yankelevitz, David; King, Jennifer (Elsevier, 2022-02)

[EN] Patients with lung cancer are especially vulnerable to coronavirus disease 2019 (COVID-19) with a greater than sevenfold higher rate of becoming infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ...
Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy

Escriche-Navarro, Blanca; Escudero-Noguera, Andrea; Lucena-Sánchez, Elena; Sancenón Galarza, Félix; García-Fernández, Alba; Martínez-Máñez, Ramón (Wiley-VCH Verlag GmbH & Co. KGaA, 2022-09)

[EN] Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in ...
New advanced anti-tumor therapies based on hybrid mesoporous nanodevices

Lucena Sánchez, Elena (Universitat Politècnica de València, 2024-06-21)

[ES] La presente tesis doctoral titulada "New advanced anti-tumor therapies based on hybrid mesoporous nanodevices" se centra en el diseño, síntesis, caracterización y evaluación de nuevos nanodispositivos híbridos ...
Non-Invasive Immunogram. A Multidimensional Approach to Characterize and Monitor Immune Status in Non-Small Cell Lung Cancer

Moreno Manuel, Andrea (Universitat Politècnica de València, 2025-04-22)

[ES] El cáncer de pulmón no microcítico (CPNM) representa un 80% de los casos de cáncer de pulmón, siendo uno de los tipos de cáncer más frecuentes y mortales. El tratamiento con inmunoterapia ha mejorado significativamente ...
Optimization of cellular silica-nanoparticle loading for tumor immunomodulation therapy

Rueda Ibáñez, María (Universitat Politècnica de València, 2024-11-20)

[ES] La inmunoterapia se presenta como un tratamiento innovador en la lucha contra el cáncer, ya que estimula los mecanismos de defensa del propio cuerpo para combatir la enfermedad. El reciente auge de la medicina de ...
Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Baldominos, Pilar; Barbera-Mourelle, Alex; Barreiro, Olga; Huang, Yu; Wight, Andrew; Cho, Jae-Won; Zhao, Xi; Estivill, Guillem; Adam, Isam; Sanchez, Xavier; McCarthy, Shannon; Schaller, Julien; Khan, Zara; Ruzo, Albert; Agudo, Judith (Elsevier, 2022-05-12)

[EN] Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but patients relapse, highlighting the need to understand the mechanisms of resistance. We discovered that in primary breast cancer, ...
Study of immune resistant mechanisms in mouse models of breast cancer

Baldominos Flores, Pilar (Universitat Politècnica de València, 2024-04-22)

[ES] La inmunoterapia es un tratamiento prometedor para el cáncer de mama triple negativo (TNBC), pero los pacientes recaen, lo que destaca la necesidad de comprender los mecanismos de resistencia. En esta tesis doctoral ...