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Listar por palabra clave "Ion channels"

Mostrando ítems 1-12 de 12

A dominant-negative form of Arabidopsis AP-3 #-adaptin improves intracellular pH homeostasis

Niñoles Rodenes, Regina; Rubio, Lourdes; García Sánchez, María J.; Fernandez, Jose A.; Bueso Ródenas, Eduardo; Alejandro Martínez, Santiago; Serrano Salom, Ramón (Wiley, 2013-05)

[EN] Intracellular pH (pHi) is a crucial parameter in cellular physiology but its mechanisms of homeostasis are only partially understood. To uncover novel roles and participants of the pHi regulatory system, we have ...
A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions

Planes Ferrer, Mª Dolores; Niñoles Rodenes, Regina; Rubio, Lourdes; Bissoli, Gaetano; Bueso Ródenas, Eduardo; Garcia-Sanchez, Maria J.; Alejandro Martínez, Santiago; González Guzmán, Miguel; Hedrich, Rainer; Rodríguez Egea, Pedro Luís; Fernandez, Jose A; Serrano Salom, Ramón (Oxford University Press (OUP), 2015-02)

[EN] The stress hormone abscisic acid (ABA) induces expression of defence genes in many organs, modulates ion homeostasis and metabolism in guard cells, and inhibits germination and seedling growth. Concerning the ...
Automatic modeling of dynamic drug-hERG channel interactions using three voltage protocols and machine learning techniques: A simulation study

Escobar-Ropero, Fernando; Gomis-Tena Dolz, Julio; Saiz Rodríguez, Francisco Javier; Romero Pérez, Lucia (Elsevier, 2022-11)

[EN] Background: Assessment of drug cardiac safety is critical in the development of new compounds and is commonly addressed by evaluating the half-maximal blocking concentration of the potassium human ether-à-go-go related ...
Converting external potential fluctuations into nonzero time-average electric currents using a single nanopore

Gómez Lozano, Vicente; Ramirez Hoyos, Patricio; Cervera Montesinos, Javier; Nasir, Saima; Ali, Mubarak; Ensinger, Wolfgang; Mafé, Salvador (American Institute of Physics (AIP), 2015-02-16)

The possibility of taking advantage of a fluctuating environment for energy and information transduction is a significant challenge in biological and artificial nanostructures. We demonstrate here directional electrical ...
Current rectification by nanoparticle blocking in single cylindrical nanopores

Ali, Mubarak; Ramirez Hoyos, Patricio; Nasir, Saima; Nguyen, Quoc-Hung; Ensinger, Wolfgang; Mafé, Salvador (Royal Society of Chemistry, 2014-07-09)

Blocking of a charged pore by an oppositely charged nanoparticle can support rectifying properties in a cylindrical nanopore, as opposed to the usual case of a fixed asymmetry in the pore geometry and charge distribution. ...
Estudio mediante modelado y simulación de la relación entre la excitabilidad en neuronas y el nivel de expresión de sus canales iónicos

Martínez Zaplana, Marta (Universitat Politècnica de València, 2023-10-24)

[ES] En este trabajo se han desarrollado diferentes códigos software en MATLAB para realizar un estudio sobre la excitabilidad de las neuronas y averiguar cómo afecta la expresión de sus canales iónicos en esta. El modelo ...
Lessons Learned from Multi-scale Modeling of the Failing Heart

Gómez García, Juan Francisco; Cardona-Urrego, Karen Eliana; Trénor Gomis, Beatriz Ana (Elsevier, 2015-12)

[EN] Heart failure constitutes a major public health problem worldwide. Affected patients experience a number of changes in the electrical function of the heart that predispose to potentially lethal cardiac arrhythmias. ...
Modelado computacional del comportamiento electrofisiológico de neuronas en entorno de programación "Neuron"

Baima Samper, Tomás (Universitat Politècnica de València, 2022-10-13)

[ES] Los modelos computacionales se han utilizado desde hace décadas para simular el comportamiento electrofisiológico de células excitables tales como las neuronas. Aunque generalmente se emplean lenguajes o entornos de ...
Nanoparticle-induced rectification in a single cylindrical nanopore: Net currents from zero time-average potentials

Ali, Mubarak; Ramirez Hoyos, Patricio; Nasir, Saima; Nguyen, Quoc-Hung; Ensinger, Wolfgang; Mafé, Salvador (American Institute of Physics (AIP), 2014-01-27)

Rectification in nanopores is usually achieved by a fixed asymmetry in the pore geometry and charge distribution. We show here that nanoparticle blocking of a cylindrical pore induces rectifying properties that can support ...
Prediction of the effects of drugs on cardiac activity using computer simulations

Cano García, Jordi (Universitat Politècnica de València, 2021-03-22)

[ES] Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en Europa. Las arritmias cardíacas son una causa importante de muerte súbita, pero sus mecanismos son complejos. Esto denota la importancia ...
Role of potassium and pH on the initiation of sperm motility in the European eel

Vilchez Olivencia, Maria Carmen; MORINI, MARINA; Peñaranda, D.S.; Gallego Albiach, Victor; Asturiano Nemesio, Juan Francisco; Pérez Igualada, Luz María (Elsevier, 2017)

[EN] The role of potassium from the seminal plasma and/or the activation media was examined by selectively removing from this media, and by testing the use of channel inhibitors and a K-ionophore. Sperm motility was measured ...
Sodium affects the sperm motility in the European eel

Vilchez Olivencia, Maria Carmen; MORINI, MARINA; Peñaranda, D.S.; Gallego Albiach, Victor; Asturiano Nemesio, Juan Francisco; Pérez Igualada, Luz María (Elsevier, 2016-08)

[EN] The role of seminal plasma sodium and activation media sodium on sperm motility was examined by selectively removing the element from these two media, in European eel sperm. Sperm size (sperm head area) was also ...