[EN] INTRODUCTIONThe three clinical variants of frontotemporal dementia (behavioral variant [bvFTD], semantic dementia, and progressive non-fluent aphasia [PNFA]) are likely to develop over decades, from the preclinical ...
Layana-Castro, Pablo Emmanuel; Puchalt-Rodríguez, Joan Carles; García-Garví, Antonio; Sánchez Salmerón, Antonio José(MDPI AG, 2021-08-20)
[EN] Automatic tracking of Caenorhabditis elegans (C. egans) in standard Petri dishes is challenging due to high-resolution image requirements when fully monitoring a Petri dish, but mainly due to potential losses of ...
Layana Castro, Pablo Emmanuel(Universitat Politècnica de València, 2023-10-26)
[ES] El objetivo principal de esta tesis es el desarrollo de técnicas avanzadas de seguimiento de posturas para reconocimiento de comportamientos del Caenorhabditis elegans o C. elegans. El C. elegans es una clase de ...
García Garví, Antonio(Universitat Politècnica de València, 2020-10-15)
[ES] En los últimos años, los nematodos C. elegans cultivados en placas de Petri se han utilizado en muchas investigaciones relacionadas con el envejecimiento. El desarrollo de nuevas herramientas para automatizar los ...
[EN] Life history theory suggests that different body development dynamics may influence survival and future reproductive performance of organisms. The present work studied how these dynamics could influence seminal traits ...
Layana-Castro, Pablo Emmanuel; Puchalt-Rodríguez, Joan Carles; Sánchez Salmerón, Antonio José(Nature Publishing Group, 2020-12-17)
[EN] One of the main problems when monitoring Caenorhabditis elegans nematodes (C. elegans) is tracking their poses by automatic computer vision systems. This is a challenge given the marked flexibility that their bodies ...
[EN] In a global aging population, it is important to understand the factors affecting systemic aging and lifespan. Mitohormesis, an adaptive response caused by different insults affecting the mitochondrial network, triggers ...
Viejo Hernández, Helena(Universitat Politècnica de València, 2022-11-14)
[ES] Los sistemas de distribución de agua potable necesitan de un mantenimiento constante. Esto se debe a que los miles de kilómetros de tuberías se van desgastando causando grietas y rupturas que generan grandes pérdidas ...
Martínez Paredes, Eugenio Melchor(Universitat Politècnica de València, 2019-09-02)
[ES] Cualquier mejora en el conocimiento de la nutrición y el manejo de los futuros conejos reproductores debe considerarse como prioritario en la producción cunícola. Sin embargo, los principales esfuerzos en investigación ...
Planche, Vincent; Manjón Herrera, José Vicente; Mansecal, Boris; Lanuza, Enrique; Tourdias, Thomas; Catheline, Gwenaelle; Coupé, Pierrick(Oxford University Press, 2022-05-02)
[EN] The chronological progression of brain atrophy over decades, from pre-symptomatic to dementia stages, has never been formally depicted in Alzheimer's disease. This is mainly due to the lack of cohorts with long enough ...
[EN] Previous literature about the structural characterization of the human cerebellum is
related to the context of a specific pathology or focused in a restricted age range. In
fact, studies about the cerebellum maturation ...
[EN] There is no consensus in literature about lifespan brain maturation and senescence, mainly because previous lifespan studies have been performed on restricted age periods and/or with a limited number of scans, making ...
[EN] Here we report the toxicological evaluation of mesoporous silica particles (MSPs) in the nematode C. elegans. Specifically, we have investigated the effect of bare micro- (M0) and nano-sized (N0) MSPs, and their ...