Arias-Gonzalez, J. R.(Nature Publishing Group, 2017-08-08)
[EN] DNA polymerase couples chemical energy to translocation along a DNA template with a specific directionality while it replicates genetic information. According to single-molecule manipulation experiments, the polymerase-DNA ...
Morin, J.A.; Cao, F.J.; Lázaro, J.M.; Arias-Gonzalez, J. R.; Valpuesta, J.M.; Carrascosa, J.L.; Salas, M.; Ibarra, B.(Oxford University Press, 2015-04-20)
[EN] During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers ...
[EN] Genomes contain rare guanine-rich sequences capable of assembling into four-stranded helical structures, termed G-quadruplexes, with potential roles in gene regulation and chromosome stability. Their mechanical unfolding ...