[EN] Electromechanical coupling studies have described the intervention of nitric oxide and S-nitrosylation processes in Ca2+ release induced by stretch, with heterogeneous findings. On the other hand, ion channel function ...
[EN] PurposeMechanical stretch increases sodium and calcium entry into myocytes and activates the late sodium current. GS967, a triazolopyridine derivative, is a sodium channel blocker with preferential effects on the late ...
Del-Canto, Irene; Gómez-Cid, Lidia; Hernández-Romero, Ismael; Guillem Sánchez, María Salud; Fernández-Santos, María Eugenia; Atienza, Felipe; Such, Luis; Fernández-Avilés, Francisco; Chorro, Francisco J.; Martínez Climent, Batiste Andreu(Frontiers Media SA, 2020-08-04)
[EN] Background Mechanical stretch increases Na(+)inflow into myocytes, related to mechanisms including stretch-activated channels or Na+/H(+)exchanger activation, involving Ca(2+)increase that leads to changes in ...