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Listar por palabra clave "Mesoporous silica nanoparticles"

Mostrando ítems 1-20 de 48

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A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles

Godoy-Reyes, Tania Mariel; Llopis-Lorente, Antoni; García-Fernández, Alba; Gaviña, Pablo; Costero, Ana M.; Villalonga, Reynaldo; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Royal Society of Chemistry, 2019-04-07)

[EN] We report herein a l-glutamate (l-Glu)-responsive delivery system. It consists of Janus Au-mesoporous silica (MS) nanoparticles functionalized with l-glutamate oxidase on the Au face and with self-immolative arylboronate ...
A sensitive nanosensor for the in situ detection of the cannibal drug

Garrido-García, Eva María; Alfonso-Navarro, María; Díaz de Greñu-Puertas, Borja; Marcos Martínez, María Dolores; Costero, Ana M.; Gil Grau, Salvador; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (American Chemical Society, 2020-09-25)

[EN] A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4- methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous ...
Avidin-gated mesoporous silica nanoparticles for signal amplification in electrochemical biosensor

Jimenez-Falcao, Sandra; Parra-Nieto, Jorge; Pérez-Cuadrado, Hugo; Martínez-Máñez, Ramón; Martínez-Ruiz, Paloma; Villalonga, Reynaldo (Elsevier, 2019-11)

[EN] We report herein a novel sensing strategy for electrochemical biosensors, by using mesoporous silica nanoparticles loaded with the redox probe methylene blue and capped with an avidin/imminobiotin stimulus-responsive ...
Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles

Garrido-Cano, Iris; Candela-Noguera, Vicente; Herrera, Guadalupe; Cejalvo, Juan Miguel; Lluch, Ana; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Eroles, Pilar; Martínez-Máñez, Ramón (Elsevier, 2021-01)

[EN] We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol ...
Biocompatible Phenylboronic-Acid-Capped ZnS Nanocrystals Designed As Caps in Mesoporous Silica Hybrid Materials for on-Demand pH-Triggered Release In Cancer Cells

Salinas Soler, Yolanda; Hoerhager, Carolin; García-Fernández, Alba; Resmini, Marina; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Brueggemann, Oliver (American Chemical Society, 2018)

[EN] Biocompatible ZnS-based nanocrystals capped with 4-mercaptophenylboronic acid (ZnS@B) have been size-designed as excellent pH responsive gatekeepers on mesoporous silica nanoparticles (MSNs), which encapsulate fluorophore ...
Capped Mesoporous Silica Nanoparticles for the Selective and Sensitive Detection of Cyanide

El Sayed, Sameh; Licchelli, Maurizio; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (John Wiley & Sons, 2017-10-18)

[EN] The development of easy and affordable methods for the detection of cyanide is of great significance due to the high toxicity of this anion and the potential risks associated with its pollution. Herein, optical detection ...
Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Blandez, Juan F.; Candela-Noguera, Vicente; Lluch, Ana; Bermejo, Begoña; Sancenón Galarza, Félix; Cejalvo, Juan Miguel; Martínez-Máñez, Ramón; Eroles, Pilar (American Chemical Society, 2023-08)

[EN] Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations ...
Desarrollo de nanodispositivos terapéuticos aplicados a enfermedades relacionadas con procesos de senescencia

Galiana Guillem, Irene (Universitat Politècnica de València, 2016-05-25)

[EN] The main goal of the current project is the design and synthesis of new nanomaterials for the detection and elimination of senescent cells, focused on the treatment of senescence-related diseases such as idiopathic ...
Design and development of new bio-gated nanodevices for targeted controlled drug release

Ultimo, Amelia (Universitat Politècnica de València, 2019-10-28)

[ES] La presente tesis doctoral, titulada "Diseño y desarrollo de nuevos nanodispositivos con puertas biomoleculares para la liberación dirigida y controlada de fármacos", está centrada en el diseño, síntesis, caracterización ...
Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents

Giménez Morales, Cristina (Universitat Politècnica de València, 2016-04-22)

[EN] The present PhD thesis, which is entitled "Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents" is focused on the development of new functional ...
Design of new hybrid nanomaterials with molecular gates as nanodevices for therapeutic applications

Mas Font, Nuria (Universitat Politècnica de València, 2015-03-30)

La presente tesis doctoral, que lleva por título “Diseño de nuevos nanomateriales híbridos con puertas moleculares como nanodispositivos para aplicaciones terapéuticas” está centrada en el desarrollo de nuevos materiales ...
Drug delivery nanosystems for the localized treatment of glioblastoma multiforme

Nam, L.; Coll Merino, Mª Carmen; Erthal, L.C.S.; De La Torre-Paredes, Cristina; Serrano,D.; Martínez-Máñez, Ramón; Santos-Martinez, M.J.; Ruiz Hernández, E. (MDPI AG, 2018-05)

[EN] Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the ...
Electronic Devices for the Combination of Electrically Controlled Drug Release, Electrostimulation, and Optogenetic Stimulation for Nerve Tissue Regeneration

Monreal Trigo, Javier (Universitat Politècnica de València, 2023-06-02)

[ES] La capacidad de las células madre para proliferar formando distintas células especializadas les otorga la potencialidad de servir de base para terapias efectivas para patologías cuyo tratamiento era inimaginable hasta ...
Enzyme-controlled mesoporous nanosensor for the detection of living Saccharomyces cerevisiae

Jiménez-Falcao, Sandra; Villalonga, Anabel; Arévalo-Villena, María; Briones-Pérez, Ana; Martínez-Máñez, Ramón; Martínez-Ruíz, Paloma; Villalonga, Reynaldo (Elsevier, 2020-01-15)

[EN] We report herein the construction of an integrated and sensitive enzyme-powered colorimetric nanosensor for the quantification of living Saccharomyces cerevisiae. The nanodevice is provided with a pH-sensitive ...
Finely tuned temperature-controlled cargo release using paraffin-capped mesoporous silica nanoparticles

Aznar Gimeno, Elena; Mondragón Martínez, Laura; Ros-Lis, José Vicente; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Soto Camino, Juan; Pérez Payá, Enrique; AMOROS DEL TORO, PEDRO (Wiley-VCH Verlag, 2011-09-27)

Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle ...
Fluorogenic Sensing of Carcinogenic Bisphenol A using Aptamer-Capped Mesoporous Silica Nanoparticles

Ribes, Àngela; Aznar, Elena; Bernardos Bau, Andrea; Marcos Martínez, María Dolores; Amorós, Pedro; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (John Wiley & Sons, 2017)

[EN] Mesoporous silica nanoparticles loaded with rhodamine B and capped with a bisphenol A aptamer were used for the selective and sensitive detection of this lethal chemical. The pores of the nanoparticles are selectively ...
Gated materials for on-command release of guest molecules

Aznar, Elena; Oroval, Mar; Pascual, Lluís; Murguía, Jose R.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2016-01-27)

[EN] Multidisciplinary research at the forefront of the field of hybrid materials has paved the way to the development of endless examples of smart devices. One appealing concept in this fertile field is related to the ...
Gated Mesoporous Silica Nanocarriers for a "two-Step" Targeted System to Colonic Tissue

Gonzalez-Alvarez, Marta; Coll Merino, Mª Carmen; Gonzalez-Alvarez, Isabel; Giménez Morales, Cristina; Aznar, Elena; Martínez-Bisbal, M.Carmen; Lozoya Agulló, Isabel; Bermejo, M.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2017)

[EN] Colon targeted drug delivery is highly relevant not only to treat colonic local diseases but also for systemic therapies. Mesoporous silica nanoparticles (MSNs) have been demonstrated as useful systems for controlled ...
Gated Mesoporous Silica Nanoparticles for Biomedical Applications

Otri, Ismael (Universitat Politècnica de València, 2023-07-06)

[ES] Esta tesis doctoral titulada "Nanopartículas de sílice mesoporosas funcionalizadas con puertas moleculares para aplicaciones biomédicas" está centrada en el diseño y la síntesis de nuevos nanosistemas sensores y ...
Gated nanomaterials as delivery platform for the treatment of inflammatory disorders

García Fernández, Alba (Universitat Politècnica de València, 2020-11-08)

[ES] La presente tesis doctoral titulada "Nanomateriales con puertas moleculares como plataforma de liberación controlada de fármacos para el tratamiento de desórdenes inflamatorios" se centra la preparación y evaluación ...