Porlán Miñarro, Antonio(Universitat Politècnica de València, 2021-10-08)
[ES] El parto prematuro está asociado a resultados adversos en el desarrollo del neonato. En este aspecto, la leche materna y su composición juegan un papel importante en el correcto desarrollo del neonato, ya que es un ...
[EN] Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5¿-terminal nucleotide is important for sRNA sorting into different AGOs. Here we show that microRNA (miRNA) duplex ...
Muñoz del Campo, Ester(Universitat Politècnica de València, 2022-07-13)
[ES] La esclerosis múltiple es una enfermedad que conlleva la desmielinización y neurodegeneración del sistema nervioso central. Sus síntomas presentan variaciones en cuanto al inicio, progreso y manifestaciones clínicas ...
Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Blandez, Juan F.; Candela-Noguera, Vicente; Lluch, Ana; Bermejo, Begoña; Sancenón Galarza, Félix; Cejalvo, Juan Miguel; Martínez-Máñez, Ramón; Eroles, Pilar(American Chemical Society, 2023-08)
[EN] Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations ...
Ruiz Tórtola, Ángela(Universitat Politècnica de València, 2021-09-02)
[ES] El interés en desarrollar biosensores de alta sensibilidad para identificar y cuantificar una amplia gama de moléculas ha aumentado notablemente durante las últimas décadas en numerosos campos de aplicación. Entre ...
The majority of non-small-cell lung cancer (NSCLC) patients present with locally advanced (35%) or metastatic disease (40%); in this setting, it is of the utmost importance to balance efficacy with toxicity. However, with ...
Boix Sánchez, Olga(Universitat Politècnica de València, 2014-11-28)
[EN] The molecular mechanisms underlying human diseases, like MELAS and MERRF
syndromes, are caused by mutations in mitochondrial (mt) tRNA genes, like mt-tRNALeu(UUR) and
mt-tRNALys genes. These mutations are thought ...
Reinal-Ferre, Ignacio; Ontoria-Oviedo, Imelda; Selva, Marta; Casini, Marilù; Peiró-Molina, Esteban; Fambuena-Santos, Carlos; Climent, Andreu M.; Balaguer, Julia; Cañete, Adela; Mora, Jaume; Raya, Ángel; Sepúlveda, Pilar(MDPI, 2023-07)
[EN] Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there has been a concomitant ...
Cuperus, Josh T.; CARBONELL, ALBERTO; Fahlgren, Noah; Garcia-Ruiz, Hernan; Burke, Russell T.; Takeda, Atsushi; Sullivan, Christopher M.; Gilbert, Sunny D.; Montgomery, Taiowa A.; Carrington, James C.(Nature Publishing Group, 2010-08)
[EN] NA interference pathways can involve amplification of secondary siRNAs by RNA-dependent RNA polymerases. In plants, RDR6-dependent secondary siRNAs arise from transcripts targeted by some microRNAs (miRNAs). Here, ...