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Listar por palabra clave "Next-generation sequencing"

Mostrando ítems 1-13 de 13

Analysis of the Gut Microbiota: An Emerging Source of Biomarkers for Immune Checkpoint Blockade Therapy in Non-Small Cell Lung Cancer

Zhang, Feiyu; Ferrero, Macarena; Dong, Ning; D Auria, Giuseppe; Reyes-Prieto, Mariana; Herreros-Pomares, Alejandro; Calabuig-Fariñas, Silvia; Durendez, Elena; Aparisi, Francisco; Blasco, Ana; García, Clara; Camps, Carlos; Jantus-Lewintre, Eloisa; Sirera Pérez, Rafael (MDPI AG, 2021-06)

[EN] Background: The human gut harbors around 10(13)-10(14) microorganisms, collectively referred to as gut microbiota. Recent studies have found that the gut microbiota may have an impact on the interaction between immune ...
Application of genomic tools in plant breeding

Pérez de Castro, Ana María; Vilanova Navarro, Santiago; Cañizares Sales, Joaquín; Pascual Bañuls, Laura; Blanca Postigo, José Miguel; Díez Niclós, Mª José Teresa de Jesús; Prohens Tomás, Jaime; Picó Sirvent, María Belén (Bentham Science Publishers, 2012-05)

[EN] Plant breeding has been very successful in developing improved varieties using conventional tools and methodologies. Nowadays, the availability of genomic tools and resources is leading to a new revolution of plant ...
Bases moleculares de la enfermedad de Wilson y enfermedades Wilson-like

Vidal Garcia, Clara (Universitat Politècnica de València, 2022-07-07)

[ES] La enfermedad de Wilson (EW) es un trastorno hereditario autosómico recesivo, con una prevalencia de 1/30.000, causado por mutaciones en ATP7B. Este gen codifica para una ATPasa transportadora de cobre, con expresión ...
Characterization of Circulating T Cell Receptor Repertoire Provides Information about Clinical Outcome after PD-1 Blockade in Advanced Non-Small Cell Lung Cancer Patients

Dong, Ning; Moreno-Manuel, Andrea; Calabuig-Fariñas, Silvia; Gallach, Sandra; Zhang, Feiyu; Blasco, Ana; Aparisi, Francisco; Meri-Abad, Marina; Guijarro, Ricardo; Sirera Pérez, Rafael; Camps, Carlos; Jantus-Lewintre, Eloisa (MDPI AG, 2021-06)

[EN] Despite the success of immunotherapies in lung cancer, development of new biomarkers for patient selection is urgently needed. This study aims to explore minimally invasive approaches to characterize circulating T ...
Experimental evolution of pseudogenization and gene loss in a plant RNA virus

Zwart, Mark Peter; Willemsen, Anouk; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (Oxford University Press (OUP): Molecular Biology and Evolution, 2014-01)

[EN] Viruses have evolved highly streamlined genomes and a variety of mechanisms to compress them, suggesting that genome size is under strong selection. Horizontal gene transfer has, on the other hand, played an important ...
Genética molecular y biomarcadores de la enfermedad de Wilson

Sánchez Monteagudo, Ana (Universitat Politècnica de València, 2023-05-28)

[ES] La enfermedad de Wilson (EW) es un trastorno hereditario del metabolismo del cobre causado por mutaciones en ATP7B, que codifica una proteína transportadora de cobre en el hígado. Su mal funcionamiento provoca un fallo ...
Molecular and phylogenetic identification of unique isolates of hammerhead viroid-like RNA from 'Pacific Gala' apple (Malus domestica) in Canada

Messmer, Amber; Sanderson, Daniel; Braun, Gordon; Flores Pedauye, Ricardo; Serra Alfonso, Pedro; James, Delano (Taylor & Francis, 2017)

[EN] Ten isolates of apple hammerhead viroid-like RNA (AHVd RNA) were detected by next-generation sequencing (NGS) and/or by RT-PCR analysis of apple (Malus domestica) 'Pacific Gala' (PG) from Canada. All consisted of 433 ...
Next-generation sequencing and genome editing in plant virology

Hadidi, Ahmed; Flores Pedauye, Ricardo; Candresse, Thierry; Barba, Marina (Frontiers Media, 2016-08)

[EN] Next-generation sequencing (NGS) has been applied to plant virology since 2009. NGS provides highly efficient, rapid, low cost DNA, or RNA high-throughput sequencing of the genomes of plant viruses and viroids and of ...
Optimización de un procedimiento de secuenciación de nueva generación de amplicones cortos para la identificación de alelos de riesgo de enfermedad celíaca e intolerancia a la lactosa.

Millán Castillo, Miriam (Universitat Politècnica de València, 2023-07-28)

[ES] Las intolerancias alimentarias son relativamente frecuentes en la población adulta e infantil, siendo las intolerancias al gluten (celiaquía o enfermedad celíaca (EC)) y a la lactosa (no persistencia de la lactasa) ...
Recent Advances on the Multiplex Molecular Detection of Plant Viruses and Viroids

Pallás Benet, Vicente; Sanchez Navarro, Jesús Ángel; James, D. (Frontiers Media SA, 2018)

[EN] Plant viruses are still one of the main contributors to economic losses in agriculture. It has been estimated that plant viruses can cause as much as 50 billion euros loss worldwide, per year. This situation may be ...
SILEX: a fast and inexpensive high-quality DNA extraction method suitable for multiple sequencing platforms and recalcitrant plant species

Vilanova Navarro, Santiago; Alonso-Martín, David; Gramazio, Pietro; Plazas Ávila, María de la O; García-Fortea, Edgar; Ferrante, Paola; Schmidt, Maximilian; Díez Niclós, Mª José Teresa De Jesús; Usadel, Björn; Giuliano, Giovanni; Prohens Tomás, Jaime (Springer (Biomed Central Ltd.), 2020-08-10)

[EN] Background The use of sequencing and genotyping platforms has undergone dramatic improvements, enabling the generation of a wealth of genomic information. Despite this progress, the availability of high-quality genomic ...
STATegra: Multi-Omics Data Integration - A Conceptual Scheme With a Bioinformatics Pipeline

Planell, Nuria; Lagani, Vincenzo; Sebastián-León, Patricia; van der Kloet, Frans; Ewing, Ewoud; Karathanasis, Nestoras; Urdangarin, Arantxa; Arozarena, Imanol; Jagodic, Maja; Tsamardinos, Ioannis; Tarazona, Sonia; Conesa, Ana; Tegner, Jesper; Gómez-Cabrero, David (Frontiers Media, 2021-03-04)

[EN] Technologies for profiling samples using different omics platforms have been at the forefront since the human genome project. Large-scale multi-omics data hold the promise of deciphering different regulatory layers. ...
Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants

Martinez Garcia, Fernando; Lafforgue, Guillaume; Morelli, M.; González-Candelas, F.; CHUA, N.H.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2012-11)

[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...