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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

Reig-López, Javier; M. Cuquerella-Gilabert; Bandín-Vilar, Enrique; Merino-Sanjuán, Matilde; Mangas-Sanjuán, Victor; García-Arieta, Alfredo (Elsevier, 2024-06)

[EN] The characterization of the time course of ibuprofen enantiomers can be useful in the selection of the most sensitive analyte in bioequivalence studies. Physiologically based pharmacokinetic (PBPK) modelling and ...

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