YAMANAKA, ERIC-SEITI; Tortajada-Genaro, Luis Antonio; Maquieira, A.(Springer-Verlag, 2017-05)
[EN] The costs of current genotyping methods limit their application to personalized therapy. The authors describe an alternative approach for the detection of single-point-polymorphisms using recombinant polymerase ...
[EN] Background: In advanced-stage (IIIB or IV) non-small-cell lung cancer (NSCLC), combination chemotherapy has demonstrated response rates of 20% and a 1-year survival rate of 30%. We conducted a multicentre, open-label, ...
Tortajada-Genaro, Luis Antonio; Puchades Pla, Rosa; Maquieira Catala, Ángel(Elsevier, 2017-03-20)
[EN] Diagnostic methods based on single nucleotide polymorphism (SNP) biomarkers are essential for the real adoption of personalized medicine. Allele specific amplification in a homogeneous format or combined to microarray ...