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Listar por palabra clave "Pharmacokinetics"

Mostrando ítems 1-9 de 9

Aplicación de modelos computacionales multiescala de la actividad eléctrica en la predicción de cardiotoxicidad

Cano García, Jordi (Universitat Politècnica de València, 2015-06-17)

[EN] Introduction. In the risk prediction of Torsade-de-pointes arrythmia assotiated to drug intake, electric conduction multiscale models are used but, for now, a connection between dose, plasma concentration and channel ...
Automatic Individual Arterial Input Functions Calculated From PCA Outperform Manual and Population-Averaged Approaches for the Pharmacokinetic Modeling of DCE-MR Images

Sanz Requena, Roberto; Prats-Montalbán, José Manuel; Marti Bonmati, Luis; Alberich Bayarri, Ángel; García Martí, Gracián; Pérez, Rosario; Ferrer Riquelme, Alberto José (Wiley, 2015-08)

[EN] Background: To introduce a segmentation method to calculate an automatic arterial input function (AIF) based on prin- cipal component analysis (PCA) of dynamic contrast enhanced MR (DCE-MR) imaging and compare it with ...
Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission

Rojas, Santiago; Gispert, Juan D.; Martín González, Roberto; Abad, Sergio; Menchón, Cristina; Pareto, Deborah; Víctor, Víctor M.; Alvaro Rodríguez, Maria Mercedes; García Gómez, Hermenegildo; Herance, J. Raúl (American Chemical Society, 2011)

[EN] Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently ...
Effect of surface properties in protein corona development on mesoporous silica nanoparticles

CLEMMENTS, ALDEN MICHAEL; Muniesa Lajara, Carlos; Landry, Christopher Caron; Botella Asuncion, Pablo (Royal Society of Chemistry, 2014)

[EN] The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized. Low MW serum proteins were preferentially adsorbed, and PEGylated nanoparticles did ...
Embedding R inside the PhysPK Biosimulation Software for Pharmacokinetics Population Analysis

Sánchez-Herrero, Sergio; Carbonero Martinez, Fernando; Serna, Jenifer; Cuquerella-Gilabert, Marina; Rueda-Ferreiro, Almudena; Juan, Angel A.; Calvet, Laura (Compuscript Ltd, 2023-09-13)

[EN] Background: PhysPK stands as a flexible and robust bio-simulation and modeling software designed for analysis of population pharmacokinetics (PK) and pharmacodynamics (PD) systems. PhysPK equips users with standard ...
Machine Learning Models for Predicting Personalized Tacrolimus Stable Dosages in Pediatric Renal Transplant Patients

Sanchez-Herrero, Sergio; Calvet, Laura; Juan, Angel A. (MDPI AG, 2023-10-14)

[EN] Tacrolimus, characterized by a narrow therapeutic index, significant toxicity, adverse effects, and interindividual variability, necessitates frequent therapeutic drug monitoring and dose adjustments in renal transplant ...
Methodological developments and clinical applications of pharmacokinetic models in contrast-enhanced magnetic resonance perfusion studies

Sanz Requena, Roberto (Universitat Politècnica de València, 2010-07-05)

La angiogénesis y la neovascularización son procesos biológicos que tienen lugar en los tejidos y que están asociados al aumento de las demandas de oxígeno y nutrientes. En adultos normales estos procesos no suelen ocurrir. ...
Pharmaceutical characterization and pharmacokinetics of florfenicol-loaded alginate dried beads in rabbits

Gutierrez Olvera, Lilia; Marcos Benitez, Xelhua; García-Guzmán, Perla; Monroy-Barreto, Minerva; Sumano, Héctor (Universitat Politècnica de València, 2022-06-29)

[EN] The pharmacokinetic variables of a new formulation of florfenicol included in dried bean of alginate (FADBs), its acceptance as in food medication, and its relationship with theoretical minimum inhibitory concentration ...
The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical Implications

Miri, Amir Hossein; Kamankesh, Mojtaba; Llopis-Lorente, Antoni; Liu, Chenguang; Wacker, Matthias G.; Haririan, Ismaeil; Asadzadeh Aghdaei, Hamid; Hamblin, Michael R.; Yadegar, Abbas; Rad-Malekshahi, Mazda; Zali, Mohammad Reza (Frontiers Media SA, 2022-06-27)

[EN] Helicobacter pylori (H. pylori) is a notorious, recalcitrant and silent germ, which can cause a variety of debilitating stomach diseases, including gastric and duodenal ulcers and gastric cancer. This microbe predominantly ...